It's Not JUST Idiopathic Pulmonary Fibrosis Study

  • STATUS
    Recruiting
  • End date
    Nov 11, 2022
  • participants needed
    250
  • sponsor
    University of Nottingham
Updated on 8 July 2021
ct scan
pulmonary disease
pulmonary fibrosis
fibrosis
spirometry
bronchoscopy
idiopathic pulmonary fibrosis
interstitial lung disease
lung biopsy

Summary

Study of progression of fibrosis in ILD

Description

The overall aims of this study are

  • Identify biomarkers and gene expression profiles that determine progressive fibrotic lung disease regardless of aetiology
  • To prospectively assess biomarkers which predict progressive fibrosis in patients with fibrosing lung disease of alternate aetiology, including RA-UIP, Asbestosis, Chronic Hypersensitivity Pneumonitis and Unclassifiable fibrotic lung disease
  • Investigate genetic associations and epigenetic modifications which affect fibrotic disease severity and progression
  • Prospectively evaluate longitudinal disease behaviour in patients with non IPF-fibrotic lung diseases with a view to developing composite clinical end-points for subsequent use in intervention studies in patients

Details
Condition usual interstitial pneumonia, Pulmonary Fibrosis, Lung Disease, Interstitial lung disease, interstitial lung diseases, Pulmonary Disease, Idiopathic Pulmonary Fibrosis
Treatment Quality of Life Questionnaires, Optional Bronchoscopy, Blood Samples for Biomarkers, Home Hand Held Spirometry
Clinical Study IdentifierNCT03670576
SponsorUniversity of Nottingham
Last Modified on8 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Male or female aged 18 years old
Able and willing to give written informed consent
Recently diagnosed [defined as diagnostic CT scan or surgical lung biopsy (if applicable) >1st May 2017]
An MDT diagnosis of fibrotic interstitial lung disease (reticulation, traction +/- honeycombing)
Sub Groups
Rheumatoid arthritis (rheumatologist diagnosed with anti-CCP antibodies and/or Rheumatoid Factor positive)
Asbestosis (appropriate occupational history and radiological evidence of asbestos exposure)
Chronic HP in accordance with consensus criteria (appropriate exposure history, radiological features +/- avian and fungal precipitins)
Unclassifiable fibrotic lung disease (fibrotic lung disease otherwise unclassifiable despite extensive clinical and radiological examination)
IPF in accordance with consensus criteria (ATS/ERS/JRS/ALAT guidelines) as controls

Exclusion Criteria

Participating in an interventional clinic trial
Asymptomatic Interstitial Lung Abnormalities (ILA) and normal lung function
Change in clinical phenotype from initial radiological diagnosis to screening
Acute Hypersensitivity Pneumonitis
Participants who do not possess a smartphone or have a valid email address (necessary for the home FVC readings)
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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