Targeted Correction of Plasma Sodium Levels in Hospitalized Patients With Hyponatremia

  • STATUS
    Recruiting
  • End date
    Dec 25, 2021
  • participants needed
    2278
  • sponsor
    University Hospital, Basel, Switzerland
Updated on 25 January 2021
edema
electrolytes
chronic hyponatremia
hyponatremic

Summary

Hyponatremia is the most common electrolyte disorder with a prevalence of up to 30% in hospitalized patients. While treatment of acute hyponatremia with severe clinical symptoms due to cerebral edema is undisputed and straightforward, hyponatremia in general is usually considered asymptomatic or not clinically relevant. Accordingly, a recent observational study showed that appropriate laboratory tests to evaluate the etiology of hyponatremia were obtained in less than 50% of patients, leading to 75% of patients being still hyponatremic at discharge.

This is problematic in the context of increasing evidence, revealing an association of chronic hyponatremia with adverse effects such as gait alterations and falls, attention deficits, bone loss and fractures as well as disease-associated morbidity leading to increased rates of readmissions and mortality. Yet, there is a complete lack of randomized clinical trials with the primary aim to investigate whether correction of plasma sodium concentration counteracts the elevated risk of rehospitalization and mortality.

The aim of this trial is therefore to determine the effects on mortality and rehospitalization rate of a targeted correction of plasma sodium concentration in addition to current standard care in hospitalized hyponatremic patients.

Details
Condition Hyponatremia, Low Blood Sodium (Hyponatremia)
Treatment Standard Care, Targeted correction of plasma sodium levels
Clinical Study IdentifierNCT03557957
SponsorUniversity Hospital, Basel, Switzerland
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

All adult hospitalised patients with hypotonic hyponatremia <130mmol/L

Exclusion Criteria

severe symptomatic hyponatremia in need of intensive care treatment
non-hypotonic hyponatremia with plasma osmolality >280 milliosmol (mOsm)/kg
end of life care (palliative treatment)
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