Last updated on March 2019

Olaparib and Cediranib Maleate in Treating Patients With Recurrent Refractory or Metastatic Endometrial Cancer


Brief description of study

This randomized phase II trial studies how well olaparib and cediranib maleate work in treating patients with endometrial cancer that has come back, does not respond to treatment, or has spread to other places in the body. Olaparib and cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed Study Description

PRIMARY OBJECTIVES:

I. To compare the efficacy of single-agent olaparib and the combination of olaparib and cediranib (and potentially other combination arms that may be added by subsequent amendment) versus single agent cediranib as measured by progression free survival (PFS), in patients with recurrent, persistent or metastatic endometrial cancer.

SECONDARY OBJECTIVES:

I. To compare the efficacy of single-agent olaparib and the combination of olaparib and cediranib (and potentially other combination arms that may be added by subsequent amendment) versus single-agent cediranib as measured by overall survival (OS) in patients with recurrent, persistent or metastatic endometrial cancer.

II. To compare the efficacy of single-agent olaparib and the combination of olaparib and cediranib (and potentially other combination arms may be added by subsequent amendment versus single-agent cediranib as measured by response rate in patients with recurrent, persistent or metastatic endometrial cancer.

III. To assess the safety and tolerability of single-agent cediranib, single-agent olaparib, and the combination of olaparib and cediranib (and potentially other combination arms may be added by subsequent amendment).

IV. To assess if mutations in deoxyribonucleic acid (DNA) homologous repair genes (assayed prior to all treatment and prior to the study treatment) are predictive of response to olaparib alone or in combination with cediranib. (Integrated Biomarker) V. To assess if markers of angiogenesis in serial plasma samples are associated with response to cediranib alone or in combination with olaparib. (Integrated Biomarker)

EXPLORTORY OBJECTIVES:

I. To compare the efficacy of the combination of olaparib and cediranib (and potentially other combination arms may be added by subsequent amendment) versus single agent olaparib as measured by PFS, response rate and OS, if and only if the combination is superior to the single-agent cediranib arm.

II. To assess if phosphatase and tensin homolog (PTEN) loss as assessed by immunohistochemistry (IHC) is predictive of response to olaparib alone or in combination with cediranib. (Exploratory Biomarker) III. To assess if loss of function of ARID1A assessed by immunohistochemistry (IHC) and mutational profile is predictive of response to olaparib alone or in combination with cediranib. (Exploratory Biomarker) IV. To assess if TP53 mutation status and p53 expression as assessed by IHC is associated with response to olaparib or in combination with cediranib. (Exploratory Biomarker) V. To assess if markers of angiogenesis in tissue are associated with response to cediranib alone or in combination with olaparib. (Exploratory Biomarker) VI. To assess if microsatellite instability (MSI) as assessed by loss of DNA mismatch repair (MMR) proteins is associated with response to olaparib alone or in combination with cediranib. (Exploratory Biomarker) VII. To assess if surrogate markers for the TCGA molecular subgroups p53 IHC, MSI, and mutational status of the exonuclease domain of polymerase-epsilon (POLE) are associated with response to treatment in all arms. (Exploratory Biomarker) VIII. To examine the association of the change in mutant allele frequency with response to treatment and to identify resistance mutations at the time of recurrence using ctDNA. (Exploratory Biomarker)

OUTLINE: Patients are randomized into 1 of 3 arms.

ARM I: Patients receive cediranib maleate orally (PO) once daily (QD). Courses repeat every 28 days in the absence of disease progression or unaccepted toxicity.

ARM II: Patients receive olaparib PO twice daily (BID). Courses repeat every 28 days in the absence of disease progression or unaccepted toxicity.

ARM III: Patients receive olaparib PO BID and cediranib maleate PO QD. Courses repeat every 28 days in the absence of disease progression or unaccepted toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Clinical Study Identifier: NCT03660826

Contact Investigators or Research Sites near you

Start Over

Michael J. Callahan

Saint Vincent Hospital and Health Care Center
Indianapolis, IN United States

Nicola M. Spirtos

Women's Cancer Center of Nevada
Las Vegas, NV United States

Timothy D. Moore

Strecker Cancer Center-Belpre
Belpre, OH United States

Timothy D. Moore

Adena Regional Medical Center
Chillicothe, OH United States

Peter G. Rose

Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, OH United States

Peter G. Rose

Cleveland Clinic Foundation
Cleveland, OH United States

Timothy D. Moore

Mount Carmel East Hospital
Columbus, OH United States

Timothy D. Moore

Columbus Oncology and Hematology Associates Inc
Columbus, OH United States

Timothy D. Moore

Riverside Methodist Hospital
Columbus, OH United States

Timothy D. Moore

Grant Medical Center
Columbus, OH United States

Timothy D. Moore

The Mark H Zangmeister Center
Columbus, OH United States

Timothy D. Moore

Mount Carmel Health Center West
Columbus, OH United States

Timothy D. Moore

Doctors Hospital
Columbus, OH United States

Timothy D. Moore

Delaware Health Center-Grady Cancer Center
Delaware, OH United States

Timothy D. Moore

Delaware Radiation Oncology
Delaware, OH United States

Timothy D. Moore

Grady Memorial Hospital
Delaware, OH United States

Timothy D. Moore

Fairfield Medical Center
Lancaster, OH United States

Timothy D. Moore

OhioHealth Mansfield Hospital
Mansfield, OH United States

Timothy D. Moore

Marietta Memorial Hospital
Marietta, OH United States

Timothy D. Moore

OhioHealth Marion General Hospital
Marion, OH United States

Peter G. Rose

Hillcrest Hospital Cancer Center
Mayfield Heights, OH United States

Timothy D. Moore

Knox Community Hospital
Mount Vernon, OH United States

Timothy D. Moore

Licking Memorial Hospital
Newark, OH United States

Timothy D. Moore

Newark Radiation Oncology
Newark, OH United States

Timothy D. Moore

Southern Ohio Medical Center
Portsmouth, OH United States

Timothy D. Moore

Saint Ann's Hospital
Westerville, OH United States

Timothy D. Moore

Genesis Healthcare System Cancer Care Center
Zanesville, OH United States

David Griffin

Saint Francis Hospital
Greenville, SC United States

David Griffin

Saint Francis Cancer Center
Greenville, SC United States

James J. Burke

Memorial Health University Medical Center
Savannah, GA United States

James J. Burke

Summit Cancer Care-Memorial
Savannah, GA United States

Robert J. Behrens

Iowa Methodist Medical Center
Des Moines, IA United States

Robert J. Behrens

Medical Oncology and Hematology Associates-Des Moines
Des Moines, IA United States

Robert J. Behrens

Broadlawns Medical Center
Des Moines, IA United States

Robert J. Behrens

Iowa Lutheran Hospital
Des Moines, IA United States

Robert J. Behrens

Trinity Regional Medical Center
Fort Dodge, IA United States

Robert J. Behrens

Methodist West Hospital
West Des Moines, IA United States

Katrina S. Wade

Ochsner Medical Center Jefferson
New Orleans, LA United States

Stephanie L. Gaillard

Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, MD United States

Brent J. Tierney

Nebraska Methodist Hospital
Omaha, NE United States

Janelle M. Fauci

Novant Health Presbyterian Medical Center
Charlotte, NC United States

Janelle M. Fauci

Carolina Surgical Clinic of Charlotte PA
Charlotte, NC United States

Janelle M. Fauci

Oncology Specialists of Charlotte
Charlotte, NC United States

Janelle M. Fauci

Southern Oncology Specialists-Charlotte
Charlotte, NC United States

Janelle M. Fauci

Lake Norman Hematology Oncology Specialists-Huntersville
Huntersville, NC United States

Janelle M. Fauci

Novant Health Presbyterian Medical Center Huntersville
Huntersville, NC United States

Janelle M. Fauci

Southern Oncology Specialists-Huntersville
Huntersville, NC United States

Janelle M. Fauci

Matthews Radiation Oncology Center
Matthews, NC United States

Janelle M. Fauci

Novant Health Cancer Specialists-Matthews
Matthews, NC United States

Janelle M. Fauci

Lake Norman Hematology Oncology Specialists-Mooresville
Mooresville, NC United States

Janelle M. Fauci

Lake Norman Radiation Oncology Center-Mooresville
Mooresville, NC United States

Janelle M. Fauci

Carolina Oncology Associates PA
Salisbury, NC United States

Janelle M. Fauci

Rowan Regional Medical Center
Salisbury, NC United States

Katherine M. Moxley

University of Oklahoma Health Sciences Center
Oklahoma City, OK United States

Katherine M. Moxley

Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, OK United States

Colleen C. McCormick

Legacy Good Samaritan Hospital and Medical Center
Portland, OR United States

Colleen C. McCormick

Legacy Meridian Park Hospital
Tualatin, OR United States

Abington Memorial Hospital
Abington, PA United States

Mark S. Shahin

Abington Memorial Hospital-Asplundh Cancer Pavilion
Willow Grove, PA United States

Colleen C. McCormick

Legacy Salmon Creek Hospital
Vancouver, WA United States

Jay W. Carlson

Good Samaritan Regional Health Center
Mount Vernon, IL United States

Katrina S. Wade

Ochsner Baptist Medical Center
New Orleans, LA United States

Jay W. Carlson

Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, MO United States

Jay W. Carlson

Cox Cancer Center Branson
Branson, MO United States

Jay W. Carlson

Freeman Health System
Joplin, MO United States

Jay W. Carlson

Mercy Hospital Joplin
Joplin, MO United States

Jay W. Carlson

Delbert Day Cancer Institute at PCRMC
Rolla, MO United States

Jay W. Carlson

Mercy Clinic-Rolla-Cancer and Hematology
Rolla, MO United States

Jay W. Carlson

Heartland Regional Medical Center
Saint Joseph, MO United States

Jay W. Carlson

Saint Louis Cancer and Breast Institute-South City
Saint Louis, MO United States

Jay W. Carlson

Mercy Hospital Saint Louis
Saint Louis, MO United States

Jay W. Carlson

Mercy Hospital Springfield
Springfield, MO United States

Jay W. Carlson

CoxHealth South Hospital
Springfield, MO United States

Jay W. Carlson

Mercy Hospital Washington
Washington, MO United States

Jay W. Carlson

Mercy Hospital Oklahoma City
Oklahoma City, OK United States

Albert S. DeNittis

Bryn Mawr Hospital
Bryn Mawr, PA United States

Albert S. DeNittis

Riddle Memorial Hospital
Media, PA United States

Albert S. DeNittis

Paoli Memorial Hospital
Paoli, PA United States

Albert S. DeNittis

Lankenau Medical Center
Wynnewood, PA United States

Cara A. Mathews

Women and Infants Hospital
Providence, RI United States

David Griffin

AnMed Health Cancer Center
Anderson, SC United States

Gretchen E. Glaser

Mayo Clinic Hospital
Phoenix, AZ United States

Gretchen E. Glaser

Mayo Clinic in Arizona
Scottsdale, AZ United States

Benjamin T. Marchello

Kootenai Medical Center
Coeur d'Alene, ID United States

Benjamin T. Marchello

Kootenai Cancer Center
Post Falls, ID United States

Benjamin T. Marchello

Kootenai Cancer Clinic
Sandpoint, ID United States

Thomas H. Openshaw

Eastern Maine Medical Center
Bangor, ME United States

Thomas H. Openshaw

Lafayette Family Cancer Center-EMMC
Brewer, ME United States

Gretchen E. Glaser

Mayo Clinic
Rochester, MN United States

Benjamin T. Marchello

Community Hospital of Anaconda
Anaconda, MT United States

Benjamin T. Marchello

Billings Clinic Cancer Center
Billings, MT United States

Benjamin T. Marchello

Bozeman Deaconess Hospital
Bozeman, MT United States

Benjamin T. Marchello

Benefis Healthcare- Sletten Cancer Institute
Great Falls, MT United States

Benjamin T. Marchello

Great Falls Clinic
Great Falls, MT United States

Benjamin T. Marchello

Saint Peter's Community Hospital
Helena, MT United States

Benjamin T. Marchello

Kalispell Regional Medical Center
Kalispell, MT United States

Benjamin T. Marchello

Community Medical Hospital
Missoula, MT United States

Bruce J. Averbook

MetroHealth Medical Center
Cleveland, OH United States

Terrence P. Cescon

Reading Hospital
West Reading, PA United States

Gretchen E. Glaser

Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, WI United States

Benjamin T. Marchello

Billings Clinic-Cody
Cody, WY United States

Benjamin T. Marchello

Welch Cancer Center
Sheridan, WY United States

Wiley L. Fowler

Mercy San Juan Medical Center
Carmichael, CA United States

Wiley L. Fowler

Mercy Cancer Center - Elk Grove
Elk Grove, CA United States

Wiley L. Fowler

Mercy Cancer Center - Rocklin
Rocklin, CA United States

Wiley L. Fowler

Mercy Cancer Center - Sacramento
Sacramento, CA United States

Wiley L. Fowler

Woodland Memorial Hospital
Woodland, CA United States

Thomas C. Krivak

Jefferson Hospital
Jefferson Hills, PA United States

Thomas C. Krivak

Forbes Hospital
Monroeville, PA United States

Thomas C. Krivak

Allegheny General Hospital
Pittsburgh, PA United States

Thomas C. Krivak

Wexford Health and Wellness Pavilion
Wexford, PA United States

Jessica A. Thomes Pepin

Fairview Ridges Hospital
Burnsville, MN United States

Jessica A. Thomes Pepin

Mercy Hospital
Coon Rapids, MN United States

Jessica A. Thomes Pepin

Fairview-Southdale Hospital
Edina, MN United States

Jessica A. Thomes Pepin

Unity Hospital
Fridley, MN United States

Jessica A. Thomes Pepin

Fairview Maple Grove Medical Center
Maple Grove, MN United States

Jessica A. Thomes Pepin

Minnesota Oncology Hematology PA-Maplewood
Maplewood, MN United States

Jessica A. Thomes Pepin

Saint John's Hospital - Healtheast
Maplewood, MN United States

Jessica A. Thomes Pepin

Abbott-Northwestern Hospital
Minneapolis, MN United States

Jessica A. Thomes Pepin

Hennepin County Medical Center
Minneapolis, MN United States

Jessica A. Thomes Pepin

Health Partners Inc
Minneapolis, MN United States

Jessica A. Thomes Pepin

Monticello Cancer Center
Monticello, MN United States

Jessica A. Thomes Pepin

New Ulm Medical Center
New Ulm, MN United States

Jessica A. Thomes Pepin

North Memorial Medical Health Center
Robbinsdale, MN United States

Jessica A. Thomes Pepin

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, MN United States

Jessica A. Thomes Pepin

Regions Hospital
Saint Paul, MN United States

Jessica A. Thomes Pepin

United Hospital
Saint Paul, MN United States

Jessica A. Thomes Pepin

Saint Francis Regional Medical Center
Shakopee, MN United States

Jessica A. Thomes Pepin

Lakeview Hospital
Stillwater, MN United States

Jessica A. Thomes Pepin

Ridgeview Medical Center
Waconia, MN United States

Jessica A. Thomes Pepin

Rice Memorial Hospital
Willmar, MN United States

Jessica A. Thomes Pepin

Minnesota Oncology Hematology PA-Woodbury
Woodbury, MN United States

Jessica A. Thomes Pepin

Fairview Lakes Medical Center
Wyoming, MN United States

Jessica A. Thomes Pepin

Cancer Center of Western Wisconsin
New Richmond, WI United States

Patricia S. Braly

Mary Bird Perkins Cancer Center
Baton Rouge, LA United States

Patricia S. Braly

Women's Cancer Care-Covington
Covington, LA United States

Richard L. Deming

CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, AR United States

Bobbie J. Rimel

Cedars Sinai Medical Center
Los Angeles, CA United States

Richard L. Deming

Penrose-Saint Francis Healthcare
Colorado Springs, CO United States

Richard L. Deming

Rocky Mountain Cancer Centers-Penrose
Colorado Springs, CO United States

Richard L. Deming

Porter Adventist Hospital
Denver, CO United States

Richard L. Deming

Mercy Medical Center
Durango, CO United States

Richard L. Deming

Southwest Oncology PC
Durango, CO United States

Richard L. Deming

Mountain Blue Cancer Care Center
Golden, CO United States

Richard L. Deming

Rocky Mountain Cancer Centers-Lakewood
Lakewood, CO United States

Richard L. Deming

Saint Anthony Hospital
Lakewood, CO United States

Richard L. Deming

Littleton Adventist Hospital
Littleton, CO United States

Richard L. Deming

Longmont United Hospital
Longmont, CO United States

Richard L. Deming

Rocky Mountain Cancer Centers-Longmont
Longmont, CO United States

Richard L. Deming

Parker Adventist Hospital
Parker, CO United States

Richard L. Deming

Rocky Mountain Cancer Centers-Parker
Parker, CO United States

Richard L. Deming

Rocky Mountain Cancer Centers - Pueblo
Pueblo, CO United States

Richard L. Deming

Rocky Mountain Cancer Centers-Thornton
Thornton, CO United States

Howard A. Zaren

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, GA United States

Howard A. Zaren

Summit Cancer Care-Candler
Savannah, GA United States

Bryan A. Faller

Illinois CancerCare-Bloomington
Bloomington, IL United States

Bryan A. Faller

Illinois CancerCare-Canton
Canton, IL United States

Bryan A. Faller

Memorial Hospital of Carbondale
Carbondale, IL United States

Bryan A. Faller

SIH Cancer Institute
Carterville, IL United States

Bryan A. Faller

Illinois CancerCare-Carthage
Carthage, IL United States

Bryan A. Faller

Centralia Oncology Clinic
Centralia, IL United States

Bryan A. Faller

Cancer Care Specialists of Illinois - Decatur
Decatur, IL United States

Bryan A. Faller

Decatur Memorial Hospital
Decatur, IL United States

Bryan A. Faller

Crossroads Cancer Center
Effingham, IL United States

Bryan A. Faller

Illinois CancerCare-Eureka
Eureka, IL United States

Bryan A. Faller

Illinois CancerCare-Galesburg
Galesburg, IL United States

Bryan A. Faller

Western Illinois Cancer Treatment Center
Galesburg, IL United States

Sudarshan K. Sharma

Sudarshan K Sharma MD Limited-Gynecologic Oncology
Hinsdale, IL United States

Bryan A. Faller

Illinois CancerCare-Kewanee Clinic
Kewanee, IL United States

Bryan A. Faller

Illinois CancerCare-Macomb
Macomb, IL United States

Bryan A. Faller

Illinois CancerCare-Ottawa Clinic
Ottawa, IL United States

Bryan A. Faller

Illinois CancerCare-Pekin
Pekin, IL United States

Bryan A. Faller

Illinois CancerCare-Peoria
Peoria, IL United States

Bryan A. Faller

Methodist Medical Center of Illinois
Peoria, IL United States

Bryan A. Faller

Illinois CancerCare-Peru
Peru, IL United States

Bryan A. Faller

Valley Radiation Oncology
Peru, IL United States

Bryan A. Faller

Illinois CancerCare-Princeton
Princeton, IL United States

Bryan A. Faller

Southern Illinois University School of Medicine
Springfield, IL United States

Bryan A. Faller

Springfield Clinic
Springfield, IL United States

Bryan A. Faller

Memorial Medical Center
Springfield, IL United States

Bryan A. Faller

Cancer Care Specialists of Illinois-Swansea
Swansea, IL United States

Bryan A. Faller

Southwest Illinois Health Services LLP
Swansea, IL United States

Iwona Podzielinski

Parkview Hospital Randallia
Fort Wayne, IN United States

Howard M. Gross

Reid Health
Richmond, IN United States

Richard L. Deming

Medical Oncology and Hematology Associates-West Des Moines
Clive, IA United States

Richard L. Deming

Mercy Cancer Center-West Lakes
Clive, IA United States

Richard L. Deming

Alegent Health Mercy Hospital
Council Bluffs, IA United States

Richard L. Deming

Greater Regional Medical Center
Creston, IA United States

Richard L. Deming

Medical Oncology and Hematology Associates-Laurel
Des Moines, IA United States

Richard L. Deming

Mercy Medical Center - Des Moines
Des Moines, IA United States

David P. Bender

University of Iowa/Holden Comprehensive Cancer Center
Iowa City, IA United States

Richard L. Deming

Mercy Medical Center-West Lakes
West Des Moines, IA United States

Richard L. Deming

Flaget Memorial Hospital
Bardstown, KY United States

Richard L. Deming

Commonwealth Cancer Center-Corbin
Corbin, KY United States

Richard L. Deming

Saint Joseph Radiation Oncology Resource Center
Lexington, KY United States

Richard L. Deming

Saint Joseph Hospital East
Lexington, KY United States

Richard L. Deming

Saint Joseph London
London, KY United States

Richard L. Deming

Jewish Hospital
Louisville, KY United States

Richard L. Deming

Saints Mary and Elizabeth Hospital
Louisville, KY United States

Richard L. Deming

Jewish Hospital Medical Center Northeast
Louisville, KY United States

Richard L. Deming

Jewish Hospital Medical Center South
Shepherdsville, KY United States

Maria C. Bell

Sanford Cancer Center Worthington
Worthington, MN United States

Bryan A. Faller

Parkland Health Center-Bonne Terre
Bonne Terre, MO United States

Bryan A. Faller

Saint Francis Medical Center
Cape Girardeau, MO United States

Bryan A. Faller

Southeast Cancer Center
Cape Girardeau, MO United States

Bryan A. Faller

Capital Region Southwest Campus
Jefferson City, MO United States

Bryan A. Faller

Missouri Baptist Medical Center
Saint Louis, MO United States

Bryan A. Faller

Sainte Genevieve County Memorial Hospital
Sainte Genevieve, MO United States

Bryan A. Faller

Missouri Baptist Sullivan Hospital
Sullivan, MO United States

Bryan A. Faller

Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, MO United States

Richard L. Deming

CHI Health Saint Francis
Grand Island, NE United States

Richard L. Deming

Heartland Hematology and Oncology
Kearney, NE United States

Richard L. Deming

CHI Health Good Samaritan
Kearney, NE United States

Richard L. Deming

Saint Elizabeth Regional Medical Center
Lincoln, NE United States

Richard L. Deming

Alegent Health Immanuel Medical Center
Omaha, NE United States

Richard L. Deming

Hematology and Oncology Consultants PC
Omaha, NE United States

Richard L. Deming

Alegent Health Bergan Mercy Medical Center
Omaha, NE United States

Richard L. Deming

Alegent Health Lakeside Hospital
Omaha, NE United States

Richard L. Deming

Creighton University Medical Center
Omaha, NE United States

Richard L. Deming

Midlands Community Hospital
Papillion, NE United States

Monica P. Hayes

Mount Sinai Chelsea
New York, NY United States

Monica P. Hayes

Mount Sinai Hospital
New York, NY United States

Timothy J. Vanderkwaak

Hope Women's Cancer Centers-Asheville
Asheville, NC United States

Howard M. Gross

Indu and Raj Soin Medical Center
Beavercreek, OH United States

Howard M. Gross

Dayton Physicians LLC-Miami Valley South
Centerville, OH United States

Howard M. Gross

Miami Valley Hospital South
Centerville, OH United States

Richard L. Deming

Good Samaritan Hospital - Cincinnati
Cincinnati, OH United States

Howard M. Gross

Oncology Hematology Care Inc-Kenwood
Cincinnati, OH United States

Richard L. Deming

Bethesda North Hospital
Cincinnati, OH United States

Richard L. Deming

TriHealth Cancer Institute-Westside
Cincinnati, OH United States

Richard L. Deming

TriHealth Cancer Institute-Anderson
Cincinnati, OH United States

Howard M. Gross

Good Samaritan Hospital - Dayton
Dayton, OH United States

Howard M. Gross

Miami Valley Hospital
Dayton, OH United States

Howard M. Gross

Dayton Physicians LLC-Samaritan North
Dayton, OH United States

Howard M. Gross

Armes Family Cancer Center
Findlay, OH United States

Howard M. Gross

Blanchard Valley Hospital
Findlay, OH United States

Howard M. Gross

Orion Cancer Care
Findlay, OH United States

Howard M. Gross

Atrium Medical Center-Middletown Regional Hospital
Franklin, OH United States

Howard M. Gross

Dayton Physicians LLC-Atrium
Franklin, OH United States

Howard M. Gross

Dayton Physicians LLC-Wayne
Greenville, OH United States

Howard M. Gross

Wayne Hospital
Greenville, OH United States

Howard M. Gross

Greater Dayton Cancer Center
Kettering, OH United States

Howard M. Gross

First Dayton Cancer Care
Kettering, OH United States

Howard M. Gross

Kettering Medical Center
Kettering, OH United States

Howard M. Gross

Springfield Regional Cancer Center
Springfield, OH United States

Howard M. Gross

Springfield Regional Medical Center
Springfield, OH United States

Howard M. Gross

Dayton Physicians LLC-Upper Valley
Troy, OH United States

Howard M. Gross

Upper Valley Medical Center
Troy, OH United States

Maria C. Bell

Sanford Cancer Center Oncology Clinic
Sioux Falls, SD United States

David C. Starks

Avera Cancer Institute
Sioux Falls, SD United States

Maria C. Bell

Sanford USD Medical Center - Sioux Falls
Sioux Falls, SD United States

Richard L. Deming

Memorial Hospital
Chattanooga, TN United States

Richard L. Deming

Pulmonary Medicine Center of Chattanooga-Hixson
Hixson, TN United States

Richard L. Deming

Memorial GYN Plus
Ooltewah, TN United States

Richard L. Deming

Saint Joseph Regional Cancer Center
Bryan, TX United States

Richard L. Deming

Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, WA United States

Richard L. Deming

Harrison Medical Center
Bremerton, WA United States

Richard L. Deming

Highline Medical Center-Main Campus
Burien, WA United States

Richard L. Deming

Saint Elizabeth Hospital
Enumclaw, WA United States

Richard L. Deming

Saint Francis Hospital
Federal Way, WA United States

Richard L. Deming

Saint Clare Hospital
Lakewood, WA United States

Richard L. Deming

Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, WA United States

Richard L. Deming

Franciscan Research Center-Northwest Medical Plaza
Tacoma, WA United States

Richard L. Deming

Northwest Medical Specialties PLLC
Tacoma, WA United States

Gregory A. Masters

Beebe Medical Center
Lewes, DE United States

Gregory A. Masters

Delaware Clinical and Laboratory Physicians PA
Newark, DE United States

Gregory A. Masters

Helen F Graham Cancer Center
Newark, DE United States

Gregory A. Masters

Medical Oncology Hematology Consultants PA
Newark, DE United States

Gregory A. Masters

Regional Hematology and Oncology PA
Newark, DE United States

Gregory A. Masters

Christiana Care Health System-Christiana Hospital
Newark, DE United States

Gregory A. Masters

Beebe Health Campus
Rehoboth Beach, DE United States

Gregory A. Masters

Nanticoke Memorial Hospital
Seaford, DE United States

Gregory A. Masters

Christiana Care Health System-Wilmington Hospital
Wilmington, DE United States

John W. Moroney

University of Chicago Comprehensive Cancer Center
Chicago, IL United States

John W. Moroney

UC Comprehensive Cancer Center at Silver Cross
New Lenox, IL United States

John W. Moroney

University of Chicago Medicine-Orland Park
Orland Park, IL United States

Linda Van Le

UNC Lineberger Comprehensive Cancer Center
Chapel Hill, NC United States

Sareena Singh

Aultman Health Foundation
Canton, OH United States

Gregory A. Masters

Christiana Care Health System-Concord Health Center
Chadds Ford, PA United States

Benjamin B. Bridges

Anchorage Associates in Radiation Medicine
Anchorage, AK United States

Benjamin B. Bridges

Anchorage Radiation Therapy Center
Anchorage, AK United States

Benjamin B. Bridges

Alaska Breast Care and Surgery LLC
Anchorage, AK United States

Benjamin B. Bridges

Alaska Oncology and Hematology LLC
Anchorage, AK United States

Benjamin B. Bridges

Alaska Women's Cancer Care
Anchorage, AK United States

Benjamin B. Bridges

Anchorage Oncology Centre
Anchorage, AK United States

Benjamin B. Bridges

Katmai Oncology Group
Anchorage, AK United States

Benjamin B. Bridges

Providence Alaska Medical Center
Anchorage, AK United States

Kristin K. Zorn

University of Arkansas for Medical Sciences
Little Rock, AR United States

Benjamin B. Bridges

Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, CA United States

Benjamin B. Bridges

Saint Luke's Mountain States Tumor Institute
Boise, ID United States

Benjamin B. Bridges

Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, ID United States

Benjamin B. Bridges

Saint Luke's Mountain States Tumor Institute - Meridian
Meridian, ID United States

Benjamin B. Bridges

Saint Luke's Mountain States Tumor Institute - Nampa
Nampa, ID United States

Benjamin B. Bridges

Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, ID United States

Christopher J. Darus

Maine Medical Center- Scarborough Campus
Scarborough, ME United States

Benjamin B. Bridges

Saint Patrick Hospital - Community Hospital
Missoula, MT United States

Sarah F. Adams

University of New Mexico Cancer Center
Albuquerque, NM United States

Sarah F. Adams

Southwest Gynecologic Oncology Associates Inc
Albuquerque, NM United States

Sarah F. Adams

Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, NM United States

Benjamin B. Bridges

Saint Charles Health System
Bend, OR United States

Benjamin B. Bridges

Clackamas Radiation Oncology Center
Clackamas, OR United States

Benjamin B. Bridges

Providence Oncology and Hematology Care Southeast
Clackamas, OR United States

Benjamin B. Bridges

Bay Area Hospital
Coos Bay, OR United States

Benjamin B. Bridges

Providence Newberg Medical Center
Newberg, OR United States

Benjamin B. Bridges

Providence Portland Medical Center
Portland, OR United States

Benjamin B. Bridges

Providence Saint Vincent Medical Center
Portland, OR United States

Benjamin B. Bridges

Saint Charles Health System-Redmond
Redmond, OR United States

Albert S. DeNittis

Main Line Health Center-Collegeville
Collegeville, PA United States

Albert S. DeNittis

Main Line Health Center-Exton
Exton, PA United States

Benjamin B. Bridges

Providence Regional Cancer System-Aberdeen
Aberdeen, WA United States

Benjamin B. Bridges

PeaceHealth Saint Joseph Medical Center
Bellingham, WA United States

Benjamin B. Bridges

Providence Regional Cancer System-Centralia
Centralia, WA United States

Benjamin B. Bridges

Swedish Medical Center-Edmonds
Edmonds, WA United States

Benjamin B. Bridges

Providence Regional Cancer Partnership
Everett, WA United States

Benjamin B. Bridges

Swedish Cancer Institute-Issaquah
Issaquah, WA United States

Benjamin B. Bridges

Kadlec Clinic Hematology and Oncology
Kennewick, WA United States

Benjamin B. Bridges

Providence Regional Cancer System-Lacey
Lacey, WA United States

Benjamin B. Bridges

PeaceHealth Saint John Medical Center
Longview, WA United States

Benjamin B. Bridges

Pacific Gynecology Specialists
Seattle, WA United States

Benjamin B. Bridges

Swedish Medical Center-Ballard Campus
Seattle, WA United States

Benjamin B. Bridges

Kaiser Permanente Washington
Seattle, WA United States

Benjamin B. Bridges

Swedish Medical Center-First Hill
Seattle, WA United States

Benjamin B. Bridges

Swedish Medical Center-Cherry Hill
Seattle, WA United States

Benjamin B. Bridges

PeaceHealth United General Medical Center
Sedro-Woolley, WA United States

Benjamin B. Bridges

Providence Regional Cancer System-Shelton
Shelton, WA United States

Benjamin B. Bridges

PeaceHealth Southwest Medical Center
Vancouver, WA United States

Benjamin B. Bridges

Providence Saint Mary Regional Cancer Center
Walla Walla, WA United States

Benjamin B. Bridges

Providence Regional Cancer System-Yelm
Yelm, WA United States

Charles A. Leath

University of Alabama at Birmingham Cancer Center
Birmingham, AL United States

John A. Ellerton

PCR Oncology
Arroyo Grande, CA United States

Richard L. Deming

Saint Mary Corwin Medical Center
Pueblo, CO United States

John A. Ellerton

Huron Medical Center PC
Port Huron, MI United States

John A. Ellerton

Lake Huron Medical Center
Port Huron, MI United States

Maria C. Bell

Sanford Joe Lueken Cancer Center
Bemidji, MN United States

Maria C. Bell

Sanford Thief River Falls Medical Center
Thief River Falls, MN United States

Jay W. Carlson

Mercy Hospital South
Saint Louis, MO United States

John A. Ellerton

Carson Tahoe Regional Medical Center
Carson City, NV United States

John A. Ellerton

Cancer and Blood Specialists-Henderson
Henderson, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada - Henderson
Henderson, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, NV United States

John A. Ellerton

Las Vegas Cancer Center-Henderson
Henderson, NV United States

John A. Ellerton

Nevada Cancer Specialists-Saint Rose
Henderson, NV United States

John A. Ellerton

21st Century Oncology-Henderson
Henderson, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, NV United States

John A. Ellerton

Desert West Surgery
Las Vegas, NV United States

John A. Ellerton

Nevada Cancer Specialists?Oakey
Las Vegas, NV United States

John A. Ellerton

University Medical Center of Southern Nevada
Las Vegas, NV United States

John A. Ellerton

Hope Cancer Care of Nevada
Las Vegas, NV United States

John A. Ellerton

Cancer and Blood Specialists-Shadow
Las Vegas, NV United States

John A. Ellerton

Radiation Oncology Centers of Nevada Central
Las Vegas, NV United States

John A. Ellerton

21st Century Oncology
Las Vegas, NV United States

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas, NV United States

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas, NV United States

John A. Ellerton

Radiation Oncology Centers of Nevada Southeast
Las Vegas, NV United States

John A. Ellerton

21st Century Oncology-Vegas Tenaya
Las Vegas, NV United States

John A. Ellerton

Ann M Wierman MD LTD
Las Vegas, NV United States

John A. Ellerton

Cancer and Blood Specialists-Tenaya
Las Vegas, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, NV United States

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas, NV United States

John A. Ellerton

Nevada Cancer Specialists-Tenaya
Las Vegas, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, NV United States

John A. Ellerton

Summerlin Hospital Medical Center
Las Vegas, NV United States

John A. Ellerton

Las Vegas Cancer Center-Medical Center
Las Vegas, NV United States

John A. Ellerton

21st Century Oncology-Fort Apache
Las Vegas, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada
Las Vegas, NV United States

John A. Ellerton

Nevada Cancer Specialists-Fort Apache
Las Vegas, NV United States

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, NV United States

John A. Ellerton

University Cancer Center
Las Vegas, NV United States

John A. Ellerton

Hope Cancer Care of Nevada-Pahrump
Pahrump, NV United States

John A. Ellerton

Renown Regional Medical Center
Reno, NV United States

John A. Ellerton

Saint Mary's Regional Medical Center
Reno, NV United States

John A. Ellerton

Radiation Oncology Associates
Reno, NV United States

Dan Costin

Dickstein Cancer Treatment Center
White Plains, NY United States

Joshua S. Trinidad

Novant Health Oncology Specialists-Kernersville
Kernersville, NC United States

Joshua S. Trinidad

Novant Health Oncology Specialists-Mount Airy
Mount Airy, NC United States

Joshua S. Trinidad

Novant Health Oncology Specialists-Statesville
Statesville, NC United States

Joshua S. Trinidad

Novant Health Oncology Specialists-Davidson County
Thomasville, NC United States

Joshua S. Trinidad

Novant Health Oncology Specialists-Wilkesboro
Wilkesboro, NC United States

Joshua S. Trinidad

Novant Health Forsyth Medical Center
Winston-Salem, NC United States

Joshua S. Trinidad

Novant Health Oncology Specialists
Winston-Salem, NC United States

Maria C. Bell

Sanford Bismarck Medical Center
Bismarck, ND United States

Maria C. Bell

Sanford South University Medical Center
Fargo, ND United States

Maria C. Bell

Sanford Medical Center Fargo
Fargo, ND United States

Maria C. Bell

Roger Maris Cancer Center
Fargo, ND United States

Maria C. Bell

Sanford Broadway Medical Center
Fargo, ND United States

Howard M. Gross

Miami Valley Hospital North
Dayton, OH United States

Recruitment Status: Closed


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.