Monitoring of Circulating Tumor DNA and Its Aberrant Methylation in the Surveillance of Surgical Lung Cancer Patients (MEDAL MEthylation Based Dynamic Analysis for Lung Cancer).

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    Peking University People's Hospital
Updated on 29 January 2022
lung cancer
lung carcinoma


Conduct a prospective study to confirm the value of circulating tumor DNA and its aberrant methylation in longitudinal monitoring of surgical lung cancer patients.


Studies have already demonstrated the feasibility of circulating tumor DNA as a surrogate to reveal tumor mutation status in lung cancer patients and a few researches have shown the potential ability of using circulating tumor DNA in surveillance. However, no study focused on the value of methylation status of circulating tumor DNA in the surveillance and no strict prospective study has been performed in surgical lung cancer patients.

The investigators plan to analyze the dynamic change of circulating tumor DNA and its methylation status longitudinally from preoperation to long term follow-up in surgical lung cancer patients, and compare assessment value between circulating tumor DNA detection with methylation , traditional imaging examinations and traditional blood tumor markers in the monitoring process.

Condition Non-Small Cell Lung Cancer, Pulmonary Disease, Lung Disease, Carcinoma, Vulvar Dysplasia and Carcinoma, Advanced Malignancies, Lung Neoplasm, Lung Cancer, Bronchial Neoplasm, Vulvar Dysplasia and Carcinoma, Advanced Malignancies, Lung Cancer, Lung Disease, nsclc, lung tumor, carcinomas, carcinoma lung, lung carcinoma
Clinical Study IdentifierNCT03634826
SponsorPeking University People's Hospital
Last Modified on29 January 2022

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