The Efficacy Safety and Pharmacokinetic of Antiplatelet Therapy for Vicagrel

    Not Recruiting
  • participants needed
  • sponsor
    Jiangsu vcare pharmaceutical technology co., LTD
Updated on 23 January 2021
heart disease
percutaneous coronary intervention
antiplatelet therapy


This is a multi-center, randomized, double-blind, triple-dummy, parallel-controled, dose-exploration phase II trial. Patients with coronary atherosclerotic heart disease and planned percutaneous coronary intervention PCI will be randomized after informed consent, in a 1:1:1:1 ratio to the following treatment groups: Experimental group 1 : Vicagrel 20mg loading followed by 5mg/day for 28 days; Experimental group 2 : Vicagrel 24mg loading followed by 6mg/day for 28 days; Experimental group 3 : Vicagrel 30mg loading followed by 7.5mg/day for 28 days; Control group : Clopidogrel 300mg loading followed by 75mg/day for 28 days. The primary purpose of this trial is to evaluate the efficacy, safety of vicagrel antiplatelet therapy and explore dose in patients with coronary atherosclerotic heart disease during and after PCI compared with clopidogrel.

Condition Coronary Artery Disease, Coronary heart disease, Platelet Aggregation Inhibitors, Percutaneous Coronary Intervention
Treatment Clopidogrel 75mg, Vicagrel 5mg, Vicagrel 6mg, Vicagrel 7.5mg
Clinical Study IdentifierNCT03599284
SponsorJiangsu vcare pharmaceutical technology co., LTD
Last Modified on23 January 2021

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