Last updated on February 2018

Annual MRI Versus Biannual US for Surveillance of Hepatocellular Carcinoma in Liver Cirrhosis

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Cirrhosis
  • Age: Between 40 - 99 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Male or female subject older than 40 years of age at the enrollment
  • Fulfill below conditions A and B
    1. The evidence of cirrhosis of any etiology within 12 months prior to screening Definition of cirrhosis by any of following methods
    2. Histologically by liver biopsy;
    3. Non-histologically by evidence of portal hypertension in the presence of chronic liver disease;
  • Evidence of portal hypertension, including any of followings;
  • The identification of splenomegaly on ultrasonography, CT, or MRI examinations with typical features of cirrhosis
  • The identification of esophageal or gastric varices on endoscopic examination B. Risk Index larger than 2.33; Risk Index = 1.65 (if the prothrombin activity is <=75%) + 1.41 (if the age is 50 years or older) + 0.92 (if the platelet count is <=100,000/mm3) + 0.74 (if the presence of HCV is positive).

Exclusion Criteria:

  • Presence of liver cancer or other intrahepatic malignancy
  • Has a history of malignancy within previous 5 years
  • Is pregnant or breast-feeding

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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