Last updated on September 2018

Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Hypoxic Brain Damage
  • Age: - 1 Years
  • Gender: Male or Female

Inclusion Criteria:

In order to be eligible for cooling the baby must meet all three of the following sets of criteria

  1. Be near term (typically 34wks gestation) and be aged < 6h old
  2. Have signs of early perinatal depression (EITHER 10 minute Apgar score < 5, OR pH < 7.00 within 60mins of age, OR Base Excess < -12 within 60mins of age, OR need respiratory support at 10min of age due to respiratory depression)
  3. Have signs of moderate or severe encephalopathy based on either clinical examination or on amplitude integrated aEEG assessment

Exclusion Criteria:

  1. Known congenital myopathy
  2. Known congenital neuropathy

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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