Watch and Wait as Treatment for Patients With Rectal Cancer

  • STATUS
    Recruiting
  • End date
    Apr 24, 2024
  • participants needed
    200
  • sponsor
    Sahlgrenska University Hospital, Sweden
Updated on 24 July 2021
cancer
endoscopy
rectal carcinoma
pelvic mri

Summary

A national cohort study with all patients scheduled for neoadjuvant treatment with (chemo)radiotherapy or short course radiotherapy with delayed surgery 6-8 weeks) for rectal cancer staged as cT4bNX/anycTanycN and cMRF+/anycTanycN and lateral lymph nodes on MRI (and patients that have been offered short course raditotherapy with delayed surgery due to various reasons). The tumours are positioned midrectal or low and are palpable with the finger. The patients offered this treatment after recommendations on their local multidisciplinary tumour board will be will be informed and offered to participate in the study. Patients scheduled for short course radiotherapy with immediate surgery cannot be included.

Description

Biopsies and blood from patients with rectal cancer subject to neoadjuvant treatment with (chemo)radiotherapy or radiotherapy 5x5 Gy with at least 6-8 weeks wait until surgery. All patients will be asked to answer a QoL questionnaire (appendix C) to cover their experiences of the neaodajvuant treatment. (Answered at diagnosis and at evaluation of treatment and decision of surgery or inclusion in the Watch and Wait part of the study).

All patients will undergo scheduled (chemo)radiotherapy according to national guidelines. The patients with chemoradiotherapy will be evaluated at 8-10 weeks after completed treatment (25) with pelvic MRI. After this evaluation at 8-10 weeks patients with suspected complete response or near complete response will examined according to the protocol below.

All patients that are considered to have complete response will be offered a "Watch and wait" approach with follow-up according to the protocol. They will then be followed at one of the Regional University Hospitals within their catchment are.

All patients with a palpable rectal cancer staged as cT4bNX/anycTanycN and cMRF+/anycTanycN and lateral lymph nodes on MRI (and patients that have been offered short course raditotherapy with delayed surgery due to various reasons) that does not achieve complete response will serve as control and will be treated with surgery as planned prior to initiation of (chemo)radiotherapy.

Patients with indication of complete response on follow-up MRI will undergo endoscopy, and digital rectal examination to ascertain complete response. MRI together with documentation from endoscopy will be reviewed at the Regional University Hospital to extablish agreement regarding interpretation. All the below mentioned criteria must be fullfilled to be considered complete response:

  1. No suspicious metastatic lymph nodes or evidence of remaining tumour on MRI. In the majority of cases a complete response on MRI will be seen as areas of homogeneous fibrosis. Absence of any remaining pathological tissue is seen in a minority of cases.
  2. Endoscopic examination with light/white mucosa or scar, telangiectasies. Prescence of fibrosis and oedema.
  3. No palpable tumour on clinical examination (26).

Details
Condition Colorectal Cancer, Rectal Cancer, Colon Cancer Screening, Colon cancer; rectal cancer, rectal neoplasm, rectal tumor, rectal neoplasms
Treatment MRI, Surgery, Endoscopy
Clinical Study IdentifierNCT03125343
SponsorSahlgrenska University Hospital, Sweden
Last Modified on24 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

All patients in Sweden with a palpable rectal cancer staged as
cT4bNX/anycTanycN and cMRF+/anycTanycN and lateral lymph nodes on MRI
considered appropriate for 5x5 Gy and 6-8 weeks of wait prior to surgery
according to Stockholm III (28) or a palpable rectal cancer staged as
cT4bNX/anycTanycN and cMRF+/anycTanycN and lateral lymph nodes on MRI a
planned schedule for CRT according to the Swedish National Program for rectal
cancer scheduled for neoadjuvant therapy are possible to include
The study includes two parts, where part one is optional in including
hospitals. The aim of the biopsy substudy to identify tumour and plasma
markers for complete response, thus all patients that will receive
(chemo)radiotherapy in the neoadjuvant setting are included to provide a
control for the biopsies
For the WoW part of the study all patients that achieve complete response
after neoadjuvant treatment according to the specified criteria above can be
included in the Watch and Wait protocol. In detail this includes patients
with
Midrectal or low rectal cancers that are palpable and considered with an
indication of 5x5 Gy and long wait (6-8 weeks) (the indication for waiting may
be logistics, co-morbidity, advanced age)
cT4bNX
anycTanycN and cMRF+ anycTanycN and lateral lymph nodes on MRI

Exclusion Criteria

No informed consent received for participation
Patients with rectal cancer that is scheduled for (chemo) radiotherapy but is not palpable during rectal examination (10-15 cm) as this cannot be examined by digital examination and followed as scheduled
Contraindication for MRI such as presence of non compatible metallic implants or claustrophobia
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