Last updated on August 2019

Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes Mellitus

Brief description of study

The study is a 2-arm, double blinded, multicenter, 2:1 randomized, placebo controlled clinical trial. Subjects will receive hydroxychloroquine or placebo and close monitoring for progression of T1D.

Detailed Study Description

This study is testing a medication, called hydroxychloroquine (HCQ) to assess safety and effectiveness to prevent individuals at risk of type 1 diabetes (T1D) from progressing to type 1 diabetes.

HCQ is approved by the U.S. Food and Drug Administration as a treatment for malaria, lupus, and rheumatoid arthritis. HCQ has been used extensively for treatment of autoimmune disease in adults, children, and during pregnancy. This medication has not previously been studied as a treatment to prevent T1D.

The goal of this study is to learn if HCQ can help prevent or delay progression from normal glucose tolerance (Stage 1) to abnormal glucose tolerance (Stage 2) or type 1 diabetes (Stage 3).

The study involves 5 visits in the first 6 months, then 1 visit every 6 months for the remainder of the study.

Clinical Study Identifier: NCT03428945

Find a site near you

Start Over

University of Pittsburgh

Pittsburgh, PA United States
  Connect »

Benaroya Research Institute

Seattle, WA United States
  Connect »

Barbara Davis Center

Aurora, CO United States
  Connect »

Children's Hospital Los Angeles

Los Angeles, CA United States
  Connect »

Stanford University

Stanford, CA United States
  Connect »

University of Florida

Gainesville, FL United States
  Connect »

University of Miami

Miami, FL United States
  Connect »

USF Diabetes Center

Tampa, FL United States
  Connect »

Emory Children's Center

Atlanta, GA United States
  Connect »

University of Chicago

Chicago, IL United States
  Connect »

University of Iowa

Iowa City, IA United States
  Connect »

Joslin Diabetes Center

Boston, MA United States
  Connect »

University of Minnesota

Minneapolis, MN United States
  Connect »

The Children's Mercy Hospital

Kansas City, MO United States
  Connect »

Palm Research Center, Inc.

Las Vegas, NV United States
  Connect »

UBMD Pediatrics

Buffalo, NY United States
  Connect »

Columbia University

New York, NY United States
  Connect »

The University of Oklahoma

Oklahoma City, OK United States
  Connect »

Childrens Hospital of Philadelphia

Philadelphia, PA United States
  Connect »

GHS - Pediatric Endocrinology

Greenville, SC United States
  Connect »

University of Utah

Salt Lake City, UT United States
  Connect »

University of Bristol

Bristol, United Kingdom
  Connect »