Last updated on April 2019

INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists Rivaroxaban or Aspirin Studies Non-Inferiority

Brief description of study

This program is a comprehensive evaluation of rheumatic valvular heart disease (RVHD), Atrial fibrillation (AF)/flutter and stroke.

A prospective, randomized, parallel group, open-label clinical trial of rivaroxaban versus standard vitamin K antagonists (VKA) therapy to evaluate non-inferiority of rivaroxaban to VKA, with testing for superiority if non-inferiority is satisfied.

Clinical Study Identifier: NCT02832544

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Chandigarh, India
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Clinical Hospital

San Lorenzo, Paraguay
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Palawan Medical City

Puerto Princesa City, Philippines
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Philippine Heart Center

Quezon City, Philippines
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University of Cape Town

Cape Town, South Africa
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University of Limpopo

Polokwane, South Africa
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Port Elizabeth Hospital Complex

Port Elizabeth, South Africa
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