High Oxygen Delivery to Preserve Exercise Capacity in Idiopathic Pulmonary Fibrosis Patients Treated With Nintedanib (HOPE-IPF)

  • days left to enroll
  • participants needed
  • sponsor
    University of British Columbia
Updated on 22 January 2022
pulmonary rehabilitation
idiopathic pulmonary fibrosis
pulse oximetry at rest


Glaucoma is a progressive optical neuropathy, generally associated with ocular hypertension. The treatment aims to stabilize the visual field deficiencies by lowering the intraocular pressure. Due to the fluctuation of the visual field test and re-test measures, the European recommendations are to obtain 6 visual field tests in 2 years (or one every 4 months) in order to know if the pathology is progressing despite the current treatment (or if the treatment is necessary, in cases of intraocular hypertensions). The lack of ophthalmologists renders the monitoring of a beginning glaucoma, rarely compatible with the present recommendations. It is therefore crucial to evaluate new therapeutic alternatives, when faced to a decreasing medical demography and an increase the patient's needs.

This study should allow to validate the possibility to delegate monitoring tasks to orthoptists during glaucoma surveillance. To organize the delegation of this surveillance to orthoptists would permit a better distribution of the ophthalmologist's activities.

Condition Idiopathic Pulmonary Fibrosis
Treatment 60% Oxygen, Standard of Care, Standard of Care
Clinical Study IdentifierNCT02551068
SponsorUniversity of British Columbia
Last Modified on22 January 2022


Yes No Not Sure

Inclusion Criteria

Age 19 years or older
Idiopathic Pulmonary Fibrosis (IPF) diagnosis according to American Thoracic Society and/or European Respiratory Society consensus criteria
Appropriate candidate for pulmonary rehabilitation
prescribed nintedanib by their treating physician or currently on nintedanib
minute walk distance 50m or more
Oxygen saturation 92% or more by pulse oximetry at rest while breathing room air
Clinically stable for the preceding 6 weeks

Exclusion Criteria

Contraindication to treatment with nintedanib (based on Canadian labeling)
Contraindication to exercise testing (e.g. significant cardiovascular, musculoskeletal, neurological disease)
Other significant extra-pulmonary disease that, based on clinical assessment, could impair exercise capacity and/or oxygenation
Forced vital capacity (FVC) less than 50% or Diffusion capacity for carbon monoxide (DLCO) less than 25%
Concurrent or recent participation (less than 6 months) in a pulmonary rehabilitation program
Use of prednisone greater than 10 mg/day for more than 2 weeks within 3 months of the first study visit
Use of pirfenidone within 4 weeks of screening
Significant emphysema (less than 10% volume on high resolution computed tomography (HRCT) or forced expiratory volume at one second (FEV1)/FVC less than 0.70)
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