GEN3013 Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma

  • End date
    Dec 30, 2025
  • participants needed
  • sponsor
Updated on 12 February 2022
ct scan
renal function
stem cell transplantation
chronic lymphocytic leukemia
monoclonal antibodies
measurable disease
cell transplantation
combination chemotherapy
follicular lymphoma
monoclonal protein
diffuse large b-cell lymphoma
b-cell lymphoma
mantle cell lymphoma
refractory b-cell non-hodgkin lymphoma
pet/ct scan
marginal zone lymphoma
renal function tests
large b-cell lymphoma
high grade b-cell lymphoma
anti-cd20 monoclonal antibody


The trial is an open-label, multi-center safety trial of epcoritamab GEN3013 (DuoBody-CD3xCD20). The trial consists of two parts: a dose escalation part phase 1, first-in-human (FIH) and an expansion part phase 2a.


The purpose of the escalation part of the trial is to determine the maximum tolerated dose and the recommended phase 2 dose (RP2D) as well as to establish the safety profile of epcoritamab GEN3013 (DuoBody-CD3xCD20) in patients with relapsed, progressive or refractory B-Cell Lymphoma.

In the expansion part additional patients will be treated with epcoritamab with the RP2D and the purpose is to further explore and determine the safety and efficacy of epcoritamab.

Condition Diffuse Large B-cell Lymphoma, High-grade B-cell Lymphoma, Primary Mediastinal Large B-cell Lymphoma, Follicular Lymphoma, Mantle Cell Lymphoma, Small Lymphocytic Lymphoma, Marginal Zone Lymphoma
Treatment GEN3013 (DuoBody®-CD3xCD20), Epcoritamab
Clinical Study IdentifierNCT03625037
Last Modified on12 February 2022


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