Anesthesia and Postoperative Outcome in Colorectal Cancer Patients

  • STATUS
    Recruiting
  • participants needed
    450
  • sponsor
    Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Updated on 28 January 2023

Summary

Study aims to compare the influence of TIVA and sevoflurane anesthesia with or without lidocaine on postoperative short and long term outcome in patients with colorectal cancer undergoing surgery.

As short term endpoints postoperative pain and opioid consumption, resumption of bowel function, PONV, LOS will be registered.

Long term outcome parameters include: the incidence of chronic pain, 1 and 5 years cancer recurrences incidence and mortality.

Description

Main goals

  1. Comparative evaluation of the incidence of recurrences after TIVA vs sevoflurane anesthesia
  2. Evaluation of the effect of lidocaine infusion associated with TIVA/sevoflurane on the incidence of chronic pain and of cancer recurrences and survival.

Secondary objectives

  1. Evaluation of the influence of lidocaine on postoperative outcome in patients with colorectal cancer
  2. Evaluation of the influence of lidocaine on postoperative inflammatory response
  3. Evaluation of the influence of lidocaine on the incidence and severity of postoperative pain and outcome in patients with colorectal cancer

Details
Condition Colorectal Cancer
Treatment TIVA+lidocaine, Sevoflurane+lidocaine, TIVA+placebo, Sevoflurane+placebo
Clinical Study IdentifierNCT02786329
SponsorInstitutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Last Modified on28 January 2023

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