Brain Mechanisms of Juvenile Fibromyalgia (JFM)

  • End date
    Aug 25, 2023
  • participants needed
  • sponsor
    Children's Hospital Medical Center, Cincinnati
Updated on 12 February 2022
functional magnetic resonance imaging
Accepts healthy volunteers


This study evaluates whether differences exist between adolescent females with juvenile-onset fibromyalgia and healthy controls in processing of pain and emotion at the neural level as assessed by functional magnetic resonance imaging (fMRI). The study includes a longitudinal component to evaluate changes in neural processing of pain and emotion before and after different treatment strategies.


Juvenile-onset fibromyalgia (JFM) is a chronic, widespread pain condition that primarily affects females. Previous work has shown increased sensitivity to painful and non-painful sensory stimuli in adults with fibromyalgia, as well as brain processing abnormalities associated with these stimuli. These abnormalities in adults are highly predictive of fibromyalgia status (as opposed to healthy status) in adults. Although JFM has some similar symptoms and features to fibromyalgia in adults, the neural mechanisms of JFM may be partially different, given the moment of sharp brain development characterising JFM. fMRI scans will be completed before and after different treatments for JFM (e.g. neuromuscular training + cognitive behavioral therapy, graded aerobic exercise) to investigate the effects of treatment on brain measures related to pain, fatigue and emotion processing.

Condition Fibromyalgia
Treatment Functional Magnetic Resonance Imaging
Clinical Study IdentifierNCT03612258
SponsorChildren's Hospital Medical Center, Cincinnati
Last Modified on12 February 2022


Yes No Not Sure

Inclusion Criteria

All consecutive patients at participating centres referred for high-care unit or intensive care unit admission who have suspected or known COVID-19

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