The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum

  • End date
    Dec 1, 2023
  • participants needed
  • sponsor
    Jiang Fan
Updated on 12 February 2022
anterior mediastinum
thymus hyperplasia
thymic neoplasm
mediastinal diseases


Extended thymectomy is the main treatment for thymoma and other anterior mediastinal diseases. Video-assisted thoracic surgery(VATS) plays an important role in the surgery of extended thymectomy. Now, VATS thymectomy through intercostal approach has been the commonly used minimally invasive surgical procedure for thymus surgery and is applied worldwide. But the intercostal approach may cause residue of thymus tissue and chronic pain. In 2013, doctor Marcin Zielinski form Poland reported a new technique of minimally invasive extended thymectomy performed through the VATS approach with double elevation of the sternum. And their early results proved this technique is probably the least invasive and the most complete technique of VATS thymectomy with excellent cosmetic results. Until now, doctor Jiang Fan form Shanghai Pulmonary Hospital has performed 50 cases extended thymectomy through the subxiphoid approach with double elevation of the sternum by VATS. This study is designed to compare the curative effect between this new method and traditional intercostal VATS.


This study is a prospective multicentre cohort study.The main study content is comparative study of the curative effect of extended thymectomy performed through the subxiphoid-right video-thoracoscopic approach with double elevation of the sternum versus intercostal video-thoracoscopic approach, divided into subxiphoid and intercostal groups. Communicating with the surgeon and patients who meet the inclusion criteria, decide whether to enter the subxiphoid or intercostal group. Subxiphoid group with subxiphoid-right video-thoracoscopic approach under double elevation of the sternum in extended thymectomy , intercostal group with traditional intercostal video-assisted thoracoscopic surgery in extended thymectomy. By collecting personal information of two groups of patients and the corresponding observation indicators to analyze whether the subxiphoid-right VATS approach with double elevation of the sternum is the least invasive and the most complete technique of VATS thymectomy.

Condition Thymoma, Myasthenia Gravis, Mediastinal Tumor
Treatment Subxiphoid approach extended thymectomy by VATS, Intercostal approach extended thymectomy by VATS
Clinical Study IdentifierNCT03613272
SponsorJiang Fan
Last Modified on12 February 2022


Yes No Not Sure

Inclusion Criteria

MG with thymic hyperplasia, thymoma or other anterior mediastinum disease
Masaoka staging-
Patients with normal cardio-pulmonary function before operation, BMI<30

Exclusion Criteria

Unable to tolerate surgery
Masaoka staging -
Patients who have undergone previous surgery or radiotherapy
Myasthenia crisis
Chronic pain or using opioid analgesics before surgery
Preoperative mental disorders such as excessive anxiety
Patients who underwent previous mediastinal surgery or cardiac surgery
Patients with thoracic deformity
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