Evaluation of Bioavailability and Metabolism of Diet Phenolic Compounds

Inclusion Criteria:

• Men and women from 18 to 45 years old.
• Understand and accepting the procedures of the trial and sign an informed consent.
• Have a history and physical exams that show that there is no organic issue, and an analysis and ECG in the normal limits.
• Have an BMI between 18.5 and 30 kg/m2.
• caucasian race

Exclusion Criteria:

• Smokers
• Persons with chronical disease
• Persons with BMI>30 or <18.5 kg/m2.
• Persons with history of multiple allergies or obvious intestinal, hepatic, renal issues or other problems that could suppose a deterioration of absorption, distribution or metabolism of polyphenols.
• Persons who take anti-oxidant products, including vitamins, herbal medication or dietetics complementation that could interfere in the study objectives.
• Persons with restrictive diet (including vegetarian diet).
• Persons with history of hypersensibility or intolerance to alcohol.
• Persons with a daily consumption of alcohol >50g or who have consumed illegal drug in the month preceding the study.
• Persons who have participated in an other clinical trial the month preceding the study.
• Persons who have done a blood donation during the last 3 months before the beginning of the study (only appliable to the subjects of A sub-study).
• Persons who have a positive serology for B or C hepatitis or HIV.
• Pregnant or breastfeeding women, or any other situation prohibiting alcohol consumption.
• Persons who have consummed NSAIDs (especially acetylsalicylic acid) or antioxidants or vitamin complementation, during the 2 weeks preceding the beginning of the study.
• Illiterate persons