The Detection of Barrett's Esophagus by Gastrointestinal Endoscopy Prevents Esophageal Carcinoma in Morbid Obese After Sleeve Gastrectomy (Refleeve)

  • End date
    Nov 17, 2023
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire de Nice
Updated on 5 March 2022
barrett's esophagus
sleeve gastrectomy


Severe Gastroesophageal reflux disease (GERD) leading to a chronic aggression of esophagus mucosa, called Barrett's esophagus is a main complication of Sleeve gastrectomy for morbid obesity. Barrett's esophagus is considered as a early stage of neoplastic transformation to adenocarcinoma. Since this last years, six european bariatric centers have adopted the policy to realize endoscopy before and five years or more after sleeve gastrectomy. Investigators worked out a database comprizing the Endoscopic features and patient characteristics. Refleeve projet aim to analyse the long term follow-up datas of 100 patients, evaluate the prevalence of Barret's esophagus and investigate the advantage of the systemetic detection to prevent esophagus adenocarcinomas.

Condition Gastroesophageal Reflux
Clinical Study IdentifierNCT03596411
SponsorCentre Hospitalier Universitaire de Nice
Last Modified on5 March 2022


Yes No Not Sure

Inclusion Criteria

Patients who had had SG with a minimum follow-up of 5 years, without signs of Barrett's esophagus before SG
An upper GI endoscopy before the SG
An upper GI endoscopy indicating that no Barrett's esophagus was present at the time of the SG
An upper GI endoscopy done with the scope of searching for the endoscopic anomalies of the Barrett's esophagus according to the international guidelines for the diagnosis of Barrett's esophagus 9
Endoscopic biopsies according to the international guidelines for the diagnosis of Barrett's esophagus 9

Exclusion Criteria

SG as a conversional procedure from another bariatric procedure such as the gastric banding
No upper GI endoscopy before the SG
Barrett's esophagus before the SG
A second procedure after the SG such as the conversion to Roux-en-Y gastric bypass or duodenal switch
An upper GI endoscopy done not following the international guidelines for the diagnosis of Barrett's esophagus9
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note