The Detection of Barrett's Esophagus by Gastrointestinal Endoscopy Prevents Esophageal Carcinoma in Morbid Obese After Sleeve Gastrectomy (Refleeve)

  • STATUS
    Recruiting
  • End date
    Nov 17, 2023
  • participants needed
    100
  • sponsor
    Centre Hospitalier Universitaire de Nice
Updated on 5 March 2022
esophagogastroduodenoscopy
endoscopy
barrett's esophagus
sleeve gastrectomy

Summary

Severe Gastroesophageal reflux disease (GERD) leading to a chronic aggression of esophagus mucosa, called Barrett's esophagus is a main complication of Sleeve gastrectomy for morbid obesity. Barrett's esophagus is considered as a early stage of neoplastic transformation to adenocarcinoma. Since this last years, six european bariatric centers have adopted the policy to realize endoscopy before and five years or more after sleeve gastrectomy. Investigators worked out a database comprizing the Endoscopic features and patient characteristics. Refleeve projet aim to analyse the long term follow-up datas of 100 patients, evaluate the prevalence of Barret's esophagus and investigate the advantage of the systemetic detection to prevent esophagus adenocarcinomas.

Details
Condition Gastroesophageal Reflux
Clinical Study IdentifierNCT03596411
SponsorCentre Hospitalier Universitaire de Nice
Last Modified on5 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients who had had SG with a minimum follow-up of 5 years, without signs of Barrett's esophagus before SG
An upper GI endoscopy before the SG
An upper GI endoscopy indicating that no Barrett's esophagus was present at the time of the SG
An upper GI endoscopy done with the scope of searching for the endoscopic anomalies of the Barrett's esophagus according to the international guidelines for the diagnosis of Barrett's esophagus 9
Endoscopic biopsies according to the international guidelines for the diagnosis of Barrett's esophagus 9

Exclusion Criteria

SG as a conversional procedure from another bariatric procedure such as the gastric banding
No upper GI endoscopy before the SG
Barrett's esophagus before the SG
A second procedure after the SG such as the conversion to Roux-en-Y gastric bypass or duodenal switch
An upper GI endoscopy done not following the international guidelines for the diagnosis of Barrett's esophagus9
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