Neuroinflammatory Response and Headache Control in Patients After Subarachnoid Hemorrhage (HASH4-CSF)

  • STATUS
    Recruiting
  • End date
    Dec 1, 2024
  • participants needed
    40
  • sponsor
    MaineHealth
Updated on 5 March 2022
drainage
headache
subarachnoid hemorrhage

Summary

The purpose of this study is to determine the relationship between the Neuroinflammatory response and headache pain after subarachnoid hemorrhage.

Description

Persistent headache is a significant medical issue that affects 20% of patients who survive an aneurysmal subarachnoid hemorrhage (SAH). This headache may last years, severely affecting quality of life. Laboratory evidence suggests that the persistent headache may be a result of a maladaptive neuroinflammatory response to the hemorrhage injury that is more vigorous than necessary. The goal of this study is to measure key immunomodulators in the blood and the cerebrospinal fluid of these patients in order to determine the magnitude and dynamics of their neuroinflammatory response. In addition, the investigators will collect and analyze observational data about the success of medications to treat headache, with a specific focus on the anti-inflammatory agent dexamethasone, in managing acute headache pain and preventing the development of persistent headaches in patients after SAH.

Details
Condition Subarachnoid Hemorrhage, Aneurysmal, Headache, Subarachnoid Hemorrhage
Clinical Study IdentifierNCT03604276
SponsorMaineHealth
Last Modified on5 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Non-traumatic subarachnoid hemorrhage
Age > 18 years
Treated with external ventricular drainage

Exclusion Criteria

Pregnancy or lactation
Age < 18 years
Traumatic SAH
Clear my responses

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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