Effect of Exercise on Genes That Control Muscle Function

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    30
  • sponsor
    Baylor College of Medicine
Updated on 16 February 2021

Summary

The proposed project will examine how exercise counteracts metabolic disorders and type 2 diabetes through regulating gene expression. The project is highly relevant to public health because of the global pandemic of diabetes, obesity, and associated metabolic syndromes as well as the well-known metabolic benefit of physical exercise in correcting these disorders.

Description

Exercise is a first-line treatment for type 2 diabetes, and exerts its beneficial effects not only by burning off energy but also by causing prolonged metabolic changes through changing gene expression. Genes are our genetic materials and the expression of genes determines our biology. In our previous study in animals, we identified some factors that drive exercise-induced gene expression changes. Here we would like to address whether the result is also true in human. This work will provide molecular insights into how exercise remodels our metabolism and will potentially find a way to maximize the benefit we get from physical exercise.

The purpose of this study is to determine whether acute exercise activate certain molecular factors in human skeletal muscle. Participants will be asked to undergo an acute bout of aerobic exercise at ~ moderate intensity for about 2 hours. Before and after the exercise, the participants will undergo a muscle biopsy. The muscle tissues will be used for total RNA extraction and RT-qPCR analysis of genes that include but are not limited to de facto JunD/AP-1 target genes and will also be analyzed by Jun D Chip-qPCT to assess binding of Jun D on its de facto target genes.

Details
Condition healthy
Treatment Exercise
Clinical Study IdentifierNCT03414385
SponsorBaylor College of Medicine
Last Modified on16 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 20 yrs and 40 yrs?
Gender: Male or Female
Do you have healthy?
Do you have any of these conditions: Do you have healthy??
Do you have any of these conditions: Do you have healthy??
Age 20 - 40 years
BMI 18.5 - 29.9
Stable body weight (not more than 2 kg change) during the past 6 months
Moderate sedentary (regular exercise less than 1 hour per week for the last 6 months)
Willing to provide informed consent

Exclusion Criteria

Failure to provide informed consent
Any major chronic disease or any condition that would interfere with exercise, in which exercise is contraindicated, or that would interfere with interpretation of results
Severe orthopedic and or neuromuscular disease that would contraindicate participation in exercise
Other significant co-morbid disease that would impair ability to exercise
Uncontrolled hypertension (BP greater than 160/90)
History of malignancy during the past 5 years
Diabetes mellitus as determined by self-report with verification (medical records, current treatment, confirmation from health care provider), or HbA1c of exceeding 6.5%
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