Safety and Efficacy of Midline and PICC

  • STATUS
    Recruiting
  • End date
    May 10, 2022
  • participants needed
    510
  • sponsor
    Centre hospitalier de l'Université de Montréal (CHUM)
Updated on 31 August 2021

Summary

The purpose of this study is to assess the non-inferiority for safety and efficacy of using Midline in comparison with PICC for intravenous therapy that do not require a central catheter.

Description

Vascular access devices (VADs), including peripherally inserted central venous catheters (PICCs) remain a cornerstone for the delivery of necessary intravenous therapy. PICCs are being selected for venous access more frequently today than ever before.

The advantage of PICC is that it can be used for all intravenous therapy. However, PICC requires the use of fluoroscopy or other type of guidance which add to the cost and time required to insert the catheter. Midline, on the other hand, can be inserted under ultrasound guidance, takes less time to be inserted and cost less than PICC insertion.

Despite lower cost and better accessibility of midline in comparison with PICC for non-vesicant intravenous therapy, there is very little evidence in the literature to suggest that one type of venous access is better than the other.

The primary objective of this study is to assess the non-inferiority for safety and efficacy of using Midline in comparison with PICC for intravenous therapy that do not require a central catheter.

Results of this trial will allow improving a quality of evidence for using midline instead of PICC for specified indications. If Midline are non-inferior for some indications, they would represent a more accessible and less expensive alternative than PICC insertion.

Details
Condition Diet and Nutrition, Chronic Diarrhea, Skin Wounds, Chronic Shoulder Pain, Vaginal Atrophy, Adverse Effects, Drugs, Injection Port, Breast Cancer - HER2 Positive, Anal Dysplasia, Primary Immunodeficiency, Pediatric Health, Near-Sighted Corrective Surgery, Peripheral Arterial Occlusive Disease, Brain Function, Recurrent Respiratory Papillomatosis, Central Venous Catheter, Razor Bumps (Pseudofolliculitis Barbae), Vascular Access Devices, Metastatic Triple-Negative Breast Cancer
Treatment Bard PowerPICC, Bard PowerMidline catheter
Clinical Study IdentifierNCT03502980
SponsorCentre hospitalier de l'Université de Montréal (CHUM)
Last Modified on31 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Required intra venous therapy
Expected duration of the venous access: > 6 days and < 30days

Exclusion Criteria

Patient has a contraindication to insertion of either a Midline or a PICC relative to the therapy
Patient from other hospitals who come to the CHUM only for the installation of a central line
Decreased cognitive ability to care for device at home
Preexisting bacteremia (ie, existing positive blood cultures that had not been repeated with negative results)
Preexisting venous thrombosis or known hypercoagulable states (such as protein C or S deficiency, antithrombin deficiency, lupus anticoagulant)
End-stage renal disease requiring vein preservation
Venous access with multiple lumens required
Patients not able to give informed consent
Prior participation to this study
Patient is enrolled in another investigational study
Patients hospitalized in the intensive care unit
Patients who are difficult to puncture and require multiple blood samples
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