Last updated on July 2018

Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Sudden Cardiac Death
  • Age: Between 18 - 85 Years
  • Gender: Male or Female

Inclusion Criteria:

  • 2-40 days (inclusive) following a myocardial infarct
  • Impaired left ventricular systolic function (LVEF40% or at least moderately impaired)

Exclusion Criteria:

  1. Age <18 or >85;
  2. Pregnancy;
  3. Nursing home resident dependent on one or more activities of daily living;
  4. Significant non-cardiac co-morbidity with high likelihood of death within 1 year (this would include any metastatic malignancy, or other terminal disease);
  5. Significant psychiatric illnesses that may be aggravated by device implantation or that may preclude regular follow up;
  6. Intravenous drug abuse (ongoing);
  7. Unresolved infection associated with risk for hematogenous seeding;
  8. Pre-existing implantable cardioverter-defibrillator (ICD);
  9. Secondary prevention indication for an ICD (i.e. sustained ventricular arrhythmias occurring more than 48 hours after qualifying myocardial infarction (patients with ventricular arrhythmias occurring 48 hours of myocardial infarction, or with non-sustained ventricular tachycardia at any time, are not excluded));
  10. On the heart transplant list;
  11. Recurrent unstable angina despite revascularisation (defined as ongoing chest pain or ischemic symptoms at rest or with minimal exertion despite adequate treatment with anti-anginal medications);**
  12. Congestive heart failure New York Heart Association class IV, defined as shortness of breath at rest, which is refractory to medical treatment (not responding to treatment)** **NOTE: patients who meet exclusion based on (11) or (12) can be reviewed again in 2-3 days and if symptoms have resolved or treatment performed can be re-considered for inclusion.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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