The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics

    Not Recruiting
  • End date
    Sep 23, 2024
  • participants needed
  • sponsor
    Mclean Hospital
Updated on 20 October 2022
Accepts healthy volunteers


The primary aim of this study is to investigate the effects of exogenously administered nicotinamide riboside (NR) on brain NAD+/NADH ratio and bioenergetics functions in healthy individuals using phosphorus magnetic resonance spectroscopy (31P MRS) imaging.

The secondary aims are to investigate the change in brain PCr/ATP and creatine kinase enzyme rate after NR use. In addition, NAD+/NADH ratio, PCr/ATP and CK enzyme rate will be measured in the calf muscle, as secondary outcome measures.

Condition Healthy
Treatment Nicotinamide Riboside
Clinical Study IdentifierNCT03151707
SponsorMclean Hospital
Last Modified on20 October 2022

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