The purpose of the trial is to evaluate the safety of GEN1029 (HexaBody-DR5/DR5) in a mixed population of patients with specified solid tumors
The trial is an open-label, multi-center safety trial of GEN1029 (HexaBody-DR5/DR5). The trial consists of two parts a dose escalation part (phase 1, first-in-human (FIH) and an expansion part (phase 2a). The expansion part of the trial will be initiated once the Recommended Phase 2 Dose (RP2D) has been determined.
| Condition | Vaginal Atrophy, Pancreatic Cancer, Gastric Carcinoma, Kidney Cancer, Triple Negative Breast Cancer, Stomach Cancer, Digestive System Neoplasms, Primary Immunodeficiency, Chronic Diarrhea, Renal Cancer, Renal Cell Cancer, Islet Ce417ll Cancer, clear cell renal cell carcinoma, Pancreatic disorder, Colon Cancer Screening, Recurrent Respiratory Papillomatosis, Rectal Disorders, Pancreatic Disorders, Breast Cancer, Pediatric Health, Skin Wounds, nsclc, Diet and Nutrition, cancer of the pancreas, pancreatic cancers, Injection Port, Razor Bumps (Pseudofolliculitis Barbae), Breast Cancer - HER2 Positive, Non-Small Cell Lung Cancer, Stomach Discomfort, cancer, pancreatic, Rectal disorder, Colon cancer; rectal cancer, Adverse Effects, Drugs, Malignant Adenoma, Gastropathy, colorectal tumor, cancer, colorectal, Renal Cell Carcinoma, Anal Dysplasia, Urothelial Cancer, colorectal cancers, gastric cancers, Brain Function, tumors, colorectal, Metastatic Triple-Negative Breast Cancer, Peripheral Arterial Occlusive Disease, colorectal neoplasm, Neoplasm of unspecified nature of digestive system, Adenocarcinoma, Chronic Shoulder Pain, Near-Sighted Corrective Surgery, Colorectal Cancer, Malignant neoplasm of kidney, Gastric Cancer |
|---|---|
| Treatment | GEN1029 (HexaBody®-DR5/DR5) |
| Clinical Study Identifier | NCT03576131 |
| Sponsor | Genmab |
| Last Modified on | 16 January 2022 |
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