Pragmatic Investigation of optimaL Oxygen Targets Trial

  • STATUS
    Recruiting
  • participants needed
    2250
  • sponsor
    Vanderbilt University Medical Center
Updated on 20 October 2021
mechanical ventilation
FIO2
oximetry
assisted ventilation

Summary

Mechanical ventilation of ICU patients universally involves titration of the fraction of inspired oxygen (FiO2) to maintain arterial oxygen saturation (SpO2). Despite decades of ICU practice, however, the optimal SpO2 target remains unknown. Current guidelines offer divergent recommendations as to the optimal SpO2 target. Therefore, we propose a 2,250-patient cluster-randomized cluster-crossover trial comparing a lower SpO2 target (90%; range 88-92%), an intermediate SpO2 target (94%; range 92-96%), and a higher SpO2 target (98%; range 96-100%) with regard to the outcome of days alive and free of invasive mechanical ventilation.

Details
Condition Respiratory Failure
Treatment Lower SpO2 Target, Intermediate SpO2 Target, Higher SpO2 Target
Clinical Study IdentifierNCT03537937
SponsorVanderbilt University Medical Center
Last Modified on20 October 2021

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