TPF Induction Chemotherapy vs PF Adjuvant Chemotherapy Combined With Concurrent Chemoradiotherapy in the Treatment of Locally Advanced NPC

  • End date
    May 24, 2023
  • participants needed
  • sponsor
    Guiyang Medical University
Updated on 4 March 2022


Through randomized controlled phase III multicenter clinical trials, TPF induction chemotherapy vs. PF regimen adjuvant chemotherapy concurrently Radiotherapy and chemotherapy for the treatment of locally advanced nasopharyngeal carcinoma: the efficacy, toxicity and quality of life, and further improvement Survival rate and improve the quality of life.

Condition Locally Advanced Nasopharyngeal Carcinoma
Clinical Study IdentifierNCT03574324
SponsorGuiyang Medical University
Last Modified on4 March 2022


Yes No Not Sure

Inclusion Criteria

Patients with newly histologically confirmed non-keratinizing (according to World Health Organization (WHO) histologically type)
Clinical staged as IIIIVaaccording to the American Joint Committee on Cancer(AJCC) 7th edition
Fertility women should ensure contraception during entry into the study
Age 18-69 years old
Karnofsky scale(KPS)70
Adequate marrow: leucocyte count 4000/L, hemoglobin 90g/L and platelet count 100000/L
Normal liver function test: Alanine Aminotransferase (ALT)Aspartate Aminotransferase (AST) <1.5upper limit of normal (ULN) concomitant with alkaline phosphatase (ALP) 2.5ULN, and bilirubin ULN
Adequate renal function: creatinine clearance 60 ml/min
Patients must be informed of the investigational nature of this study and give written informed consent

Exclusion Criteria

With distant metastasis
who had received prior chemotherapy or radiotherapy
patients have physical or mental illness, and by researchers believe that patients 4.can not be completely or fully understood in this study possible complications
pregnancy (via the urine or serum -HCG test confirmed) or during lactation
serious complications, such as uncontrolled hypertension, heart failure
diabetes and so on
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