Curative Proton Beam Therapy for Patients With Lung Metastasis of Colorectal Cancer

  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    National Cancer Center, Korea
Updated on 4 March 2022
adenocarcinoma of colon


Proton alone therapy is performed

-> 5 times a week, 7200 cGy / 15 fractions for 3 weeks total


This clinical trial is a prospective, single-organ, phase II clinical trial to evaluate the efficacy of curative proton therapy for pulmonary metastasis of colon cancer diagnosed histologically as adenocarcinoma.

Patients who meet the selection criteria should be selected, signed for consent, and treated 5 times a week for 7200 cGy / 15 fractions alone for 3 weeks.

Condition Colorectal Cancer
Treatment curative proton therapy
Clinical Study IdentifierNCT03566355
SponsorNational Cancer Center, Korea
Last Modified on4 March 2022


Yes No Not Sure

Inclusion Criteria

Histologically diagnosed colon adenocarcinoma in primary or metastatic lesions
If there is no other remote metastasis other than lung, or if there is, control is possible
If there are less than 2 lung metastatic lesions
If they refuse lung surgery or surgery is inappropriate (medically unsuitable for surgery due to surgery refusal, diabetes mellitus, high blood pressure, pulmonary disease, heart disease, etc., repeated surgery, poor systematic function, short disease-free period, etc.)

Exclusion Criteria

Other histologic cancer other than adenocarcinoma of the colorectal
Colorectal cancer without primary lesion resection
If there is another remote metastasis and is not completely resected or regulated
If the patient has experience of other invasive cancer diagnosis within 5 years of colorectal cancer diagnosis
Pregnancy and women under lactation
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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