Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
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- STATUS
- Recruiting
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- End date
- Dec 31, 2022
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- participants needed
- 60
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- sponsor
- University Of Perugia
Summary
The very low carbohydrates diet (VLCKD) induces liver steatosis amelioration. Lysosomal acid lipase (LAL) deficiency plays a role in fats accumulation in liver. To date, no studies have assessed LAL activity in morbid obesity. The aim of our study is to evaluate VLCKD impact on metabolic/vascular parameters and LAL activity in obese patients.
A VLCKD is administered for 25 days to 52 morbid obese patients (BMI 44.78.3 kg/m, age 4912.5 years); at baseline and after diet we evaluated: BMI, glyco-lipidic pattern, abdominal ultrasonography (liver steatosis and visceral fat area) and flow-mediated dilation (FMD). In a subgroup of 20 patients we also tested lysosomal acid lipase (LAL)-activity. A group of healthy normal weight subjects (age 4313, BMI 22.82.6 kg/m) was also included in the study.
Details
| Condition | Lysosomal Acid Lipase Deficiency, Obesity, Ketogenic Dieting, Ketosis |
|---|---|
| Clinical Study Identifier | NCT03564002 |
| Sponsor | University Of Perugia |
| Last Modified on | 4 March 2022 |
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