Last updated on July 2019

Real-life Effectiveness of Vortioxetine in Depression


Brief description of study

Worldwide Major Depressive Disorder (MDD) has significant negative personal, societal and economic consequences.

Vortioxetine (Brintellix) is a new antidepressant authorized since 2013. Despite evidence generated from clinical trials which demonstrate that vortioxetine is an efficacious, well-tolerated antidepressant, there is a need to determine the effectiveness of vortioxetine in real life routine practice.

The study aim is to examine the real-life effectiveness of vortioxetine on functioning, depressive symptom relief, cognition and quality of life.

This is an observational, multi-national, study in patients with MDD initiating treatment with vortioxetine. Information will be collected by the physician, from the patient and their medical record at three time points - baseline, week 12 and week 24 (end of follow-up). This study will be conducted in six countries. In total 2,100 patients are planned for enrolment.

Clinical Study Identifier: NCT03555136

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Pharmacology Research Institute

Newport Beach, CA United States
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Breakthrough Clinical Trials

San Bernardino, CA United States
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Da Vinci Research Institute

Boca Raton, FL United States
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Gainesville, FL United States
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Maxblue Institute

Hialeah, FL United States
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Office Of Amit Vijapura, Md

Jacksonville, FL United States
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Professional Health Care of Pinellas

Saint Petersburg, FL United States
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Meridian Clinical Research

Savannah, GA United States
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Pearl Health Clinic

Ammon, ID United States
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Southern Illinois Associates LLC

Glen Carbon, IL United States
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AMR- Baber Research, Inc.

Naperville, IL United States
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Neuroscientific Insights

Rockville, MD United States
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Burton and Hutchens LLC

Columbia, MO United States
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US 0039 Mattingly

Saint Charles, MO United States
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Alivation Research, LLC

Lincoln, NE United States
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Meridian Clinical Research

Norfolk, NE United States
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Finger Lakes Clinical Research

Rochester, NY United States
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Psychiatric Consultants, Pc

Franklin, TN United States
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Bay Pointe Behavioral Health

Friendswood, TX United States
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Biopharma Informatic LLC

Houston, TX United States
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West park Springs

Richmond, TX United States
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Core Clinical Research

Everett, WA United States
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CA0001

Edmonton, AB Canada
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Jodha Tishon Inc

Toronto, ON Canada
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GCP Research

Montreal, QC Canada
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Mana Research Inc

Point Claire, QC Canada
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CHS Le Vinatier

Bron Cedex, France
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Cmpi

Le Vesinet, France
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Chru Houtel Dieu

Angers Cedex, France
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CH De Novillars

Chalezeule, France
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Cabinet Medical

Marseille, France
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Hopital de la Colombiere

Montpellier Cedex, France
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Hopital Nord

St Priest En Jarez Cedex, France
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Hopital civil

Strasbourg, France
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CH Thuir

Thuir, France
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Asl Roma G

Colleferro, Italy
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Recruitment Status: Open


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