Last updated on October 2018

Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Necrotizing enterocolitis | Congenital Heart Disease | Prematurity | Patent ductus arteriosus
  • Age: - 1 Years
  • Gender: Male or Female

Inclusion Criteria:

  • PDA secondary to prematurity
    1. Premature infants of 32 weeks gestational age at birth
    2. Patent ductus arteriosus diagnosed via echocardiogram
    3. Feeding volume 70 ml/kg/day
    4. Stable Clinical Condition (no vasopressors, no clinical sepsis)
    5. Age 12 days of life

Control group

  1. Premature infants of 32 weeks gestational age at birth
  2. No PDA
  3. Feeding volume 70 ml/kg/day
  4. Stable Clinical Condition (no vasopressors, no clinical sepsis)
  5. Age 12 days of life

PDA secondary to CHD and Prostaglandin E (PGE)

  1. Infants of 32 weeks gestational age at birth
  2. Ductal dependant congenital heart disease
  3. PGE infusion
  4. No prior cardiac surgery
  5. Any bolus feedings 10 ml/kg/day or more
  6. Stable Clinical Condition (no vasopressors, no clinical sepsis)
  7. Age 12 days of life

Control Group

  1. Infants of 32 weeks gestational age at birth
  2. No know congenital heart defect including PDA.
  3. No prior cardiac surgery
  4. Feeding volume 1/2 of total fluid volume ~50- 70 ml/kg/day
  5. Stable Clinical Condition (no vasopressors, no clinical sepsis)

Exclusion Criteria:

  • Lack of parental consent
  • Multiple congenital anomalies
  • Unstable clinical condition
  • Prior abdominal pathology (medical/surgical necrotizing enterocolitis within the last 14 days, gastroschisis, or other abdominal abnormality)

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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