Human Mesenchymal Stem Cells For Bronchopulmonary Dysplasia

  • participants needed
  • sponsor
    Children's Hospital of Chongqing Medical University
Updated on 6 July 2022
premature birth
severe bronchopulmonary dysplasia


This study is an open-label, single-center, dose escalation study to evaluate of safety and efficacy of human umbilical cord -derived mesenchymal stem cells (hUC-MSCs) in premature infants for moderate and severe Bronchopulmonary DysplasiaBPD.


BPD is a chronic lung disease that occur in premature infants receiving prolonged oxygen pulmonary and ventilator therapy. It remains a main complication of extreme prematurity and currently lacks efficient treatment.The mortality rate of one year after birth is still high and the quality of life is not optimistic.

hUC-MSCs are widely used in clinic due to their low immunogenicity and convenient to get.Many animal study had shown that hUC-MSCs had therapeutic effects on a variety of animal models of lung disease.Furthermore,there are a large number of clinical trials of MSCs applied to various system diseases and the safety was verified.So,the main purpose of this study is to evaluate the safety and efficacy of hUC-MSCs in participants with moderate and severe BPD.

Condition Bronchopulmonary Dysplasia
Treatment transplantation of mesenchymal stem cell, no transplantation of mesenchymal stem cell
Clinical Study IdentifierNCT03558334
SponsorChildren's Hospital of Chongqing Medical University
Last Modified on6 July 2022

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