Effect of Abstinence Duration on Embryo Development

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Universitair Ziekenhuis Brussel
Updated on 21 March 2022
Accepts healthy volunteers


The aim the investigators study is to analyze the embryo development if oocytes of the participants are injected with sperm from a longer or shorter (2 hours) abstinence duration.


Participants undergoing an IVF treatment, are asked to respect an abstinence duration of 2-7 days. This is to obtain a sufficient number of motile sperm. A recent investigation, analyzed the quality (number and motility) of a sperm sample produced after an abstinence duration of 4 to 7 days, followed by a second sperm sample 2 hours later. The second sample (after 2 hours) was able to produce sperm cells with a higher motility. Not only has this short abstinence duration of 2 hours a positive effect on the motility, it will also reduce the sperm DNA damage, which again has a positive effect on embryo development. Because participants need gametes of high quality to obtain embryos with a high quality, the investigators want to investigate what the effect is of abstinence duration on embryo development.

Condition Embryo Development
Treatment second masturbation
Clinical Study IdentifierNCT03323892
SponsorUniversitair Ziekenhuis Brussel
Last Modified on21 March 2022


Yes No Not Sure

Inclusion Criteria

Patients planned for embryo development up to day 5
at least 6 mature oocytes
fresh ejaculates
fresh embryo transfer or freeze all strategy
all stimulation protocols
concentration of >1x10^6 /ml sperm

Exclusion Criteria

IVF versus ICSI patients
chirurgical sperm
acceptors of donor oocytes
patients with PGD
patients already enrolled in another study
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