Blinatumomab Added to Prephase and Consolidation Therapy in Precursor B-acute Lymphoblastic Leukemia in Adults.

  • STATUS
    Recruiting
  • End date
    Dec 15, 2026
  • participants needed
    80
  • sponsor
    Stichting Hemato-Oncologie voor Volwassenen Nederland
Updated on 25 January 2021
Investigator
A.W. Rijneveld, Dr.
Primary Contact
Medisch Spectrum Twente (0.0 mi away) Contact
+15 other location

Summary

Blinatumomab is a new active bispecific monoclonal antibody for treatment of lymphoid malignancies, including ALL (acute Lymphoblastic Leukemia ) whose activity for remission induction needs to be explored in combination with standardized treatment in order to improve outcome of this disease which is still lethal in most adult patients. Ultimate proof of efficacy resides in an increase of reaching MRD ( minimal residual disease) negativity, prolongation of that response, and long-term survival. Since hematological response rate in adult ALL is high already and defining long-term survival in a large clinical trial takes many years, this trial aims to improve the strength of the MRD response as defined by achieving complete MRD negative response (ie, < 10^-4) after the first consolidation phase including blinatumomab. This MRD response will be assessed by Real-Time Quantitative Polymerase Chain Reaction (RQ-PCR) analysis of patient-specific Ig/TCR (T-cell receptor ) gene rearrangements. When MRD data are missing, MRD positivity will be assumed. Although younger (up to 40 years of age) patients are treated more intensively than older patients (older than 40 years of age), the investigational questions concerning blinatumomab can be examined in both subgroups as both younger and older patients receive the same type of chemotherapy courses with dose adjustments for chemotherapeutic agents only for patients above 60 years of age.

Description

This trial aims to improve the strength of the MRD ( minimal residual disease) response as defined by achieving complete MRD negative response (ie, < 10^-4) after the first consolidation phase including blinatumomab.

Details
Condition ALL, Adult, ALL, Adult, ALL, Adult, ALL, Adult, ALL, Adult
Treatment Blinatumomab
Clinical Study IdentifierNCT03541083
SponsorStichting Hemato-Oncologie voor Volwassenen Nederland
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Primary CD19 (cluster of differentiation antigen 19) positive precursor B-ALL (excluding mature B-cell ALL and B-lymphoblastic lymphoma, but including Philadelphia positive/BCR-ABL (Abelson murine leukemia viral oncogene homolog 1) positive ALL) and CD19 positive mixed phenotype acute lymphoblastic leukemia (MPAL)
Patients aged 18 to 70 years inclusive
WHO ( World Health Organization) performance status 0-2
Negative pregnancy test at inclusion, if applicable
Written informed consent
Patient is capable of giving informed consent

Exclusion Criteria

Mature B-cell leukemia/lymphoma, B-lymphoblastic lymphoma, isolated extramedullary disease
CML (Chronic myeloid leukemia) in blast crisis
Acute undifferentiated leukemia
Previous treatment with chemotherapy for precursor B-ALL (maximum 5 days of steroid treatment is allowed)
Persistent liver enzyme disorders (ASAT/ALAT) >5xULN (Upper Limit of Normal) despite steroid pre-treatment (see also 8.1.3.)
Severe cardiovascular disease (arrhythmias requiring chronic treatment, congestive heart failure or symptomatic ischemic heart disease)
Severe pulmonary dysfunction (CTCAE grade III-IV, see appendix D)
Severe neurological or psychiatric disease
Active, uncontrolled infection
Clinically overt central nervous system disease
History of active malignancy during the past 5 years with the exception of basal cell carcinoma of the skin or stage 0 cervical carcinoma
Patient known to be HIV-positive
Pregnant or breast-feeding female patients
Unwilling or not capable to use effective means of birth control (all men, all premenopausal women under the age of 50 need contraception for two years after the last period, and women older than 50 years for at least one year)
Current participation in another clinical trial
Any psychological, familial, sociological and geographical condition potentially hampering compliance with the study protocol and follow-up schedule
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