Therapeutic Control of Aspirin-Exacerbated Respiratory Disease With Ifetroban
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- STATUS
- Recruiting
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- days left to enroll
- 62
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- participants needed
- 45
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- sponsor
- Brigham and Women's Hospital
Summary
The overall aim of the study is to determine the efficacy of oral ifetroban, a novel antagonist of T prostanoid (TP) receptors, as a treatment for patients with aspirin-exacerbated respiratory disease (AERD).
Description
The protocol involves a 4-week, double-blind, placebo-controlled parallel-design trial of oral ifetroban in patients with AERD. At the end of the 4-week treatment phase (ifetroban or placebo) each subject will undergo a graded oral aspirin desensitization procedure in order to initiate high-dose aspirin therapy, which is standard-of-care at our institution and is the only available therapy known to modify the course of AERD.
Details
| Condition | Nasal Polyps, Asthma, Aspirin-Induced, Aspirin-exacerbated Respiratory Disease, Aspirin-Sensitive Asthma With Nasal Polyps |
|---|---|
| Treatment | Placebo, Ifetroban |
| Clinical Study Identifier | NCT03326063 |
| Sponsor | Brigham and Women's Hospital |
| Last Modified on | 4 March 2022 |
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