Last updated on June 2019

Naloxone Nasal Spray Compared With Naloxone Injection for Opioid Overdoses Outside the Hospital

Brief description of study

This trial will compare the clinical response to intramuscular and intranasal naloxone in pre-hospital opioid overdoses. Objective of the study is to measure and evaluate clinical response (return of spontaneous respiration within 10 minutes of naloxone administration) to a new nasal naloxone formulation in real opioid overdoses in the pre-hospital environment. The aim is to demonstrate that intranasal administration of naloxone is not clinically inferior to intramuscular administration, which is now standard treatment of care.

Clinical Study Identifier: NCT03518021

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