Last updated on June 2018

Inhaled vs IV Opioid Dosing for the Initial Treatment of Severe Acute Pain in the Emergency Department

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Emergencies [Disease/Finding] | Morphine | Pain Acute
  • Age: Between 18 - 75 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Age 18 and <75 years old;
  • EVA 70/100 or EN 7/10;
  • Patient who received clear information from the investigator and read and signed the consent form;
  • Patient affiliated with, or beneficiary of a social security category;
  • For women:

O of childbearing age: effective contraception (oral contraception, intrauterine device or use of condoms) O menopausal status (amenorrhoea less than 12 months before the inclusion visit) O objectivized sterility (diagnosis or surgically)

Exclusion Criteria:

  • Chronic pain (> 3 months)
  • Taking opioids longer than 10 days (including "weak" opioids tramadol and / or codeine);
  • Taking Rifampicin;
  • Impaired ability to discern, cognitive impairment;
  • Morphine-related contraindications:

O Obstructive chronic obstructive or restrictive respiratory failure known or suspected compensated or not, O Hypersensitivity to the active substance or to any of the excipients, O Severe hepatocellular insufficiency (known or suspected), O Chronic renal failure known or suspected, O Uncontrolled epilepsy, O Cranial trauma (intracranial hypertension), O Associations with buprenorphine, nalbuphine, pentazocine and naltrexone

  • Active drug history or practice (s);
  • Evidence of reduced fracture or dislocation in emergency rooms;
  • Suspected occlusive syndrome
  • SaO2 <95%;
  • FR <12 / min;
  • Glasgow <15 or other alertness disorders;
  • HR heart rate <50 bpm and / or Auriculo-Ventricular block (PR XML File Identifier: zR6XOYKSEQ9GjQHghP8c465EwF0= Page 15/30 interval> 200 ms);
  • Arterial hypotension with systolic blood pressure TA syst <100 mm Hg;
  • Pregnant or nursing
  • Persons deprived of their liberty by an administrative or judicial decision, a person placed under the safeguard of justice, guardianship;
  • Patients with poor comprehension of spoken or written French;
  • Patients participating in another interventional clinical study;
  • Contra-indication related to the use of saline solution
  • Contra-indications related to the use of aerosol:

O Necessity to access the face O Allergy known to plastic

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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