Monitoring of Immunological Mechanisms and Biomarkers Underlying Efficacy and Toxicity of Cancer Immunotherapy (MINER)
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- STATUS
- Recruiting
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- End date
- Nov 26, 2024
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- participants needed
- 520
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- sponsor
- Institut Claudius Regaud
Summary
This trial is a translational, open-label, multi-site, prospective cohort study of 520 patients aiming to identify and to monitor immunological biomarkers associated with therapeutic response to immune checkpoints blockade (ICB), in patients with multiple types of advanced (unresectable and/or metastatic) solid cancers.
The study will be conducted on a population of patients receiving ICB (anti-PD-1 or anti-PD-L1 or anti-CTLA4, alone or in combination) in the context of either routine care or a clinical study protocol.
Patients with any of the following tumor types may be enrolled in the trial:
- Non-Small Cell Lung Cancer (NSCLC),
- Head and neck cancer,
- Melanoma,
- Bladder cancer,
- Other tumor types when Immuno-Oncology agent is expected to be efficient or when a clinical trial is an option.
For each included patient, tumor biopsy specimens and blood samples will be collected at different time points.
All included patients will be followed-up until progression. After this date, survival data will be collected.
Details
| Condition | Solid Cancers |
|---|---|
| Treatment | Patients treated with immune checkpoint blockade |
| Clinical Study Identifier | NCT03514368 |
| Sponsor | Institut Claudius Regaud |
| Last Modified on | 26 April 2022 |
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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