Last updated on November 2019

Study of BGB-290 or Placebo in Patients With Advanced or Inoperable Gastric Cancer

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Advanced or Inoperable Gastric Cancer
  • Age: Between 18 - 99 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Age 18 years.
  2. Signed informed consent.
  3. Histologically confirmed inoperable locally advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction.
  4. Received platinum based first line chemotherapy for 28 weeks.
  5. Confirmed partial response (PR) maintained for 4 weeks or complete response (CR).
  6. Able to be randomized to study 8 weeks after last platinum dose.
  7. ECOG performance status 1.
  8. Adequate hematologic, renal and hepatic function.
  9. Must be able to provide archival tumor tissue for central biomarker assessment.
  10. Females of childbearing potential and non-sterile males must agree to use highly effective methods of birth control throughout the course of study and at least up to 6 months after last dosing.

Exclusion Criteria:

  1. Unresolved acute effects of prior therapy Grade 2.
  2. Prior treatment with PARP inhibitor.
  3. Chemotherapy, biologic therapy, immunotherapy or other anticancer therapy 14 days prior to randomization.
  4. Major surgery or significant injury 2 weeks prior to start of study treatment.
  5. Diagnosis of myelodysplastic syndrome (MDS) or active bleeding disorder.
  6. Other diagnoses of significant malignancy
  7. Leptomeningeal disease or brain metastasis
  8. Inability to swallow capsules or disease affecting gastrointestinal function.
  9. Active infections requiring systemic treatment.
  10. Clinically significant cardiovascular disease
  11. Pregnant or nursing females.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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