The Effects of Bariatric Surgeries on Glucose Metabolism

  • End date
    Aug 27, 2026
  • participants needed
  • sponsor
    The University of Texas Health Science Center at San Antonio
Updated on 27 August 2023
bariatric surgery
sleeve gastrectomy
Accepts healthy volunteers


The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.


The purpose of this study is to determine the weight-independent effects of gastric bypass surgery and sleeve gastrectomy surgery on islet cell response after meal ingestion as mediated by hormonal and neural components of the gut. It will also address the differences between the two procedures.

Such information will be critical for the development of novel approaches for treatment of diabetes as well as improvement of glycemic effects of gastric bypass and sleeve gastrectomy in patients with partial diabetes remission or relapse after complete remission.

Condition Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass
Treatment atropine, exendin-(9-39)
Clinical Study IdentifierNCT02823665
SponsorThe University of Texas Health Science Center at San Antonio
Last Modified on27 August 2023


Yes No Not Sure

Inclusion Criteria

Hypoglycemic RYGB patients with documented blood glucose level <50 mg/dl
Asymptomatic individuals with bariatric surgery
Healthy non-surgical patients with no personal history of diabetes
Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center

Exclusion Criteria

Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin <11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies
RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea
Healthy non-surgical patients with personal history of diabetes
For administration of atropine, the following exclusions also apply
History of glaucoma
Uncontrolled hypertension (any subjects with BP>140/90 and history of dyslipidemia
Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
Myasthenia gravis
Brain pathology
Enlarged prostate in men
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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