Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function

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  • sponsor
    Nantes University Hospital
Updated on 13 June 2021
kidney transplant
cardiac arrest
circulatory arrest
induced hypothermia
therapeutic hypothermia
delayed graft function


Each year, only one third of patients registered on the waiting list receive a kidney transplant. Numerous paths are being explored with the aim of reversing this shortage. The first is to increase the number of organs by developing harvesting from donors in a state of brain-death (BD) termed "expanded criteria donors" or from patients deceased from circulatory arrest.

Another fundamental factor is to insure the success of the transplant by limiting the dysfunction of donor kidneys, marked by a delayed graft function (DFG).

The development of techniques to insure correct perfusion of harvested organs, and the optimization of reanimation and intensive care of brain-dead donors constitute important factors in DGF reduction.

Therapeutic Hypothermia could to be an attractive care strategy for BD patients.

Condition organ donor, Hypothermia, Brain Death, Critical Illness, Kidney Transplant; Complications, Kidney Transplant; Complications, Kidney Transplant; Complications, Kidney Transplant; Complications, critically ill, Kidney Transplant; Complications
Treatment Procedure control: normothermia, Procedure active
Clinical Study IdentifierNCT03098706
SponsorNantes University Hospital
Last Modified on13 June 2021

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