Therapeutic Vaccine Plus PD-1 Knockout in Prostate Cancer Treatment

  • STATUS
    Recruiting
  • participants needed
    30
  • sponsor
    The First Affiliated Hospital of Guangdong Pharmaceutical University
Updated on 25 September 2021
androgens
testosterone
metastasis
vaccine therapy

Summary

This study is to evaluate the safety and efficacy of a therapeutic vaccine in combination with PD-1 knockout T cells in the treatment of advanced prostate cancer.

Description

This is a phase 1/2 clinical study investigating the safety and efficacy of a therapeutic vaccine in combination with PD-1 knockout T cells in the treatment of advanced prostate cancer. The therapeutic vaccine is a customized product involving ex vivo treatment of the patient's peripheral blood mononuclear cells with a recombinant fusion protein (PAP-GM-CSF) to activate the expression of the antigen that would activate the immune function to kill cancer cells. The PD-1 knockout engineered T cells are also prepared using patient's T cells in which PD-1 gene will be knocked out using CRISPR Cas9 technology. The therapeutic vaccine and PD-1 knockout T cells will be infused back to the patient in 3 times with a 2-week interval.

Details
Condition Malignant neoplasm of prostate, Prostatic disorder, Prostate Disorders, Prostate Cancer, Early, Recurrent, Prostate Cancer, prostate carcinoma, prostate cancers
Treatment PD-1 Knockout T Cells, Therapeutic vaccine
Clinical Study IdentifierNCT03525652
SponsorThe First Affiliated Hospital of Guangdong Pharmaceutical University
Last Modified on25 September 2021

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