Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation (CANVAS-II)

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Beijing Tiantan Hospital
Updated on 4 October 2022


There is few randomized controlled clinical to investigated the impact of anesthetic type on outcome in patients with acute ischemic stroke in posterior cerebral circulation. It is unknown whether the choice of anesthesia is impacted on the outcomes for these patients or not. The investigators will perform a randomized controlled pilot clinical trial of general anesthesia versus local anesthesia/conscious sedation to explore and find out a potential fact whether anesthetic type alters perioperative neurological function in patients with acute ischemic stroke in posterior cerebral circulation.

Condition Posterior Circulation Brain Infarction
Treatment General anesthesia, local anesthesia, Controlled ventilation, Spontaneous breath, Local anesthesia/concious sedation
Clinical Study IdentifierNCT03317535
SponsorBeijing Tiantan Hospital
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Patients with acute ischemic stroke in posterior cerebral circulation scheduled to receive emergency endovascular treatment; Age > 18; The onset time is within 24 hours; Modified rankin score ≤2 before onset

Exclusion Criteria

Radiological ambiguity concerning infarction and vessel occlusion; Additional intracerebral hemorrhage; Anterior circulation infraction; Coma on admission (Glasgow coma score less than 8); NIHSS less than 6 or more than 30; Severe agitation or seizures on admission; Obvious loss of airway protective reflexes and/or vomiting on admission; Being intubated before treatment on admission; Known allergy to anesthetic or analgesic
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