Impact of Escitalopram on Sperm DNA Fragmentation
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- STATUS
- Recruiting
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- End date
- Dec 31, 2023
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- participants needed
- 70
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- sponsor
- Weill Medical College of Cornell University
Summary
Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation. Hormone profiles, semen analysis, sperm DNA fragmentation, and sexual function will be measured at baseline, after 6 weeks of therapy, and 4 weeks after discontinuation of therapy (10 weeks into study).
Description
SSRI medications, specifically escitalopram is a very commonly prescribed medication among men of reproductive age. Significant evidence exists that they may be harmful for paternal fertility potential in both animal and human studies. However, high quality data is lacking, particularly among commonly used SSRI's such as escitalopram. As such, it is important to properly evaluate the potential effect of escitalopram in a randomized placebo controlled fashion. Results will be important in guiding urologists, psychiatrists and family practitioners regarding discussion surrounding SSRI use in their patients interested in fertility.
Details
| Condition | Sperm DNA Fragmentation, Infertility, Male |
|---|---|
| Treatment | Placebo, Escitalopram |
| Clinical Study Identifier | NCT03527043 |
| Sponsor | Weill Medical College of Cornell University |
| Last Modified on | 9 May 2022 |
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