To determine whether the musculoskeletal adaptations to bone-loading exercise can be
significantly augmented in older women (aged 60-85) with low bone mass (osteopenia; T-scores
<-1.0 and >-2.5) or moderate osteoporosis (T-scores < -2.5 and >= -3.0) and by restoring
serum DHEAS to young adult levels by oral DHEA replacement.
This will be the first study to measure changes in areal bone mineral density (aBMD) and
fat-free mass (FFM) in response to dehydroepiandrosterone (DHEA) alone and combined with
exercise in postmenopausal women. The body of evidence from carefully executed Randomized
Controlled Studies (RCTs) provides support for DHEA therapy to increase aBMD and FFM in older
women. Less is known about whether DHEA therapy enhances the effects of exercise on the aging
musculoskeletal system when an appropriate mechanical stimulus is applied.
Low Bone Mass
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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