Last updated on March 2020

DANHEART (H-HeFT and Met-HeFT)


Brief description of study

The present study is testing in a combined design to types of drugs in patients with chronic heart failure: 1) Hydralazine in combination with isosorbide dinitrate (BiDil) and 2) Metformin hydrochloride. The study is double blind, placebo controlled.

  1. The first hypothesis is that hydralazine in combination with isosorbide dinitrate can reduce mortality and hospitalization with worsening heart failure.
  2. The second hypothesis is that treatment of underlying insulin resistance/ type 2 diabetes with metformin in heart failure patients with moderately to severely reduced LVEF can reduce mortality and cardiovascular hospitalizations. Among secondary endpoints are reduction in new-onset diabetes in heart failure patients with insulin resistance and diabetes risk profile and patient safety.

Clinical Study Identifier: NCT03514108

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Amager Hospital

Copenhagen, Denmark
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Gentofte Hospital

Copenhagen, Denmark
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Glostrup Hospital

Copenhagen, Denmark
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Herlev Hospital

Copenhagen, Denmark
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Hvidovre Hospital

Copenhagen, Denmark
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Rigshospitalet

Copenhagen, Denmark
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Recruitment Status: Open


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