Effect of Pyridostigmine (Mestinon) on Muscle Strength in Myasthenia Gravis

  • participants needed
  • sponsor
    University of Aarhus
Updated on 23 September 2021


A randomized, placebo-controlled, double-blinded cross-over study evaluating and quantifying the effect of pyridostigmine on muscle strength and symptoms in Myasthenia Gravis (MG)


The study aims to evaluate and quantify the effect of pyridostigmine on symptoms and muscle strength in newly-diagnosed patients and patients on stable medication.

Pyridostigmine treatment is initiated in the vast majority of MG patients. No studies have quantified the effect in a randomized trial, and no studies have examined the potential difference in effect in newly diagnosed patients as compared to patients on stable, antimyasthenic medications.

The study will investigate the effect in two groups

  1. Newly diagnosed, treatment-naive patients.
  2. MG patients on stable antimyasthenic medication.

Condition Myasthenia Gravis, Myasthenia Gravis generalised, Myasthenia Gravis (Chronic Weakness)
Treatment pyridostigmine, Placebo oral capsule
Clinical Study IdentifierNCT03510546
SponsorUniversity of Aarhus
Last Modified on23 September 2021

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