Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression
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- STATUS
- Recruiting
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- End date
- Dec 31, 2022
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- participants needed
- 20
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- sponsor
- Dartmouth-Hitchcock Medical Center
Summary
The standard Johns Hopkins' regimen will be used in study subjects, with the use of donor peripheral blood stem cells, rather than marrow. Clinical outcomes will be defined while focusing efforts on immune reconstitution focusing on immune checkpoint regulators after a related haploidentical stem cell transplant.
Details
| Condition | Monoclonal gammopathy, Lymphoma, Preleukemia, Acute myeloid leukemia, Myelosclerosis with myeloid metaplasia, Lymphoproliferative Disorder, Lymphoma, Chronic Lymphocytic Leukemia, MYELOPROLIFERATIVE DISORDER, MYELODYSPLASTIC SYNDROME, Chronic myeloid leukemia, Lymphocytic Leukemia, Chronic, Non-Hodgkin's Lymphoma, Myelodysplastic Syndromes (MDS), Acute Myelogenous Leukemia (AML), Myeloproliferative Neoplasms, Myelofibrosis, Lymphoproliferative disorders, myelodysplasia, myelodysplastic syndromes, myeloproliferative neoplasm, myeloproliferative disorders, non-hodgkin's lymphoma (nhl), plasma cell dyscrasia, leukemia chronic lymphocytic, chronic lymphocytic leukemia (cll), small lymphocytic lymphoma, lymphomas, myelodysplastic syndrome (mds), acute myelogenous leukemia, anll, acute myeloblastic leukemia, chronic myelogenous leukemia |
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| Treatment | G-CSF, cyclophosphamide, Fludarabine, Tacrolimus, Total body irradiation, CellCept, Peripheral Blood Transplant |
| Clinical Study Identifier | NCT03480360 |
| Sponsor | Dartmouth-Hitchcock Medical Center |
| Last Modified on | 24 January 2021 |
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