Last updated on February 2018

Defining the Skin and Blood Biomarkers of Pediatric Atopic Dermatitis

Brief description of study

Atopic dermatitis (AD), also known as eczema, is the most common inflammatory skin disorder of children, affecting 10-20% of children and 1-2% of adults.

This skin disorder can be associated with unbearable itchiness and an increased susceptibility to skin infections. The cause of AD is currently poorly understood; therefore, there are no targeted treatment options at present. There have been recent studies in adults with AD that explain the cause and give us new routes to investigate treatment options, however no major studies in this arena have been done in children. We hope to evaluate the skin and blood biomarkers that are found in pediatric AD and compare them to adult AD.

Hypothesis: The immune system worsens the skin barrier issues that are common in atopic dermatitis. We believe there are similar immune and skin abnormalities in adult versus pediatric atopic dermatitis. Finally, blood levels of the activated molecules in atopic dermatitis can serve as surrogates for skin immune activation and will correlate with disease severity.

Detailed Study Description

  1. To define the cellular and molecular biomarkers of atopic dermatitis in skin biopsies and blood samples from a pre-adolescent pediatric population and correlate it with disease severity.
  2. To measure the skin barrier in atopic dermatitis.
  3. To determine quality of life in atopic dermatitis through various questionnaires.

Clinical Study Identifier: NCT01782703

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Amy Paller, MD

Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, IL United States
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Amy Paller, MD

Northwestern University
Chicago, IL United States
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Amy Paller

Northbrook Lurie Children's Outpatient Clinic
Northbrook, IL United States
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Emma Guttman, MD, PhD

Rockefeller University
New York, NY United States
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