Lymphocyte Markers As Predictors Of Responsiveness To Rituximab Among Patients With Idiopathic Nephrotic Syndrome

  • End date
    Dec 23, 2025
  • participants needed
  • sponsor
    National University Health System, Singapore
Updated on 3 March 2022
minimal change disease
steroid-resistant nephrotic syndrome


The purpose of this study is to investigate if lymphocyte markers predict response to rituximab among patients with idiopathic nephrotic syndrome

Condition Nephrotic Syndrome
Treatment Rituximab
Clinical Study IdentifierNCT03501459
SponsorNational University Health System, Singapore
Last Modified on3 March 2022


Yes No Not Sure

Inclusion Criteria

Age 1-18 years old at the time of diagnosis of nephrotic syndrome
Steroid-dependent (SDNS) or steroid-resistant nephrotic syndrome (SDNS)

Exclusion Criteria

eGFR <60 ml/min per 1.73m2
infantile onset of nephrotic syndrome
nephrotic syndrome secondary to chronic infections such as hepatitis B, hepatitis C or human immunodeficiency virus, systemic lupus erythematosus, Henoch-Schnlein purpura, IgA nephropathy, membranoproliferative glomerulonephritis or membranous nephropathy
current or previous therapy for tuberculosis
presence of mutations in WT1, NPHS1, NPHS2 and TRPC6
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