Lymphocyte Markers As Predictors Of Responsiveness To Rituximab Among Patients With Idiopathic Nephrotic Syndrome

  • STATUS
    Recruiting
  • End date
    Dec 23, 2025
  • participants needed
    100
  • sponsor
    National University Health System, Singapore
Updated on 23 January 2021
rituximab
minimal change disease
steroid-resistant nephrotic syndrome

Summary

The purpose of this study is to investigate if lymphocyte markers predict response to rituximab among patients with idiopathic nephrotic syndrome

Details
Condition Nephrotic Syndrome, Nephrotic Syndrome
Treatment Rituximab
Clinical Study IdentifierNCT03501459
SponsorNational University Health System, Singapore
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 1-18 years old at the time of diagnosis of nephrotic syndrome
Steroid-dependent (SDNS) or steroid-resistant nephrotic syndrome (SDNS)

Exclusion Criteria

eGFR <60 ml/min per 1.73m2
infantile onset of nephrotic syndrome
nephrotic syndrome secondary to chronic infections such as hepatitis B, hepatitis C or human immunodeficiency virus, systemic lupus erythematosus, Henoch-Schnlein purpura, IgA nephropathy, membranoproliferative glomerulonephritis or membranous nephropathy
current or previous therapy for tuberculosis
presence of mutations in WT1, NPHS1, NPHS2 and TRPC6
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