A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) (PERFECT)

    Not Recruiting
  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    United Therapeutics
Updated on 20 October 2022
pulmonary disease
forced expiratory volume
right heart catheterization
left ventricular end-diastolic pressure


The primary objective of this study is to demonstrate the efficacy of inhaled treprostinil compared to placebo in improving exercise ability as measured by change from baseline in 6-Minute Walk Distance (6MWD) following 12 weeks of active treatment in participants with PH-COPD.


This is a multicenter, randomized, double-blind, placebo-controlled, 34-week, cross-over study, with a Treatment Period of approximately 26 weeks under the Original Crossover Design or, if applicable, a 21-week parallel study, with a Treatment Period of approximately 14 weeks under the Contingent Parallel Design.

Condition Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
Treatment Placebo solution, Inhaled treprostinil solution
Clinical Study IdentifierNCT03496623
SponsorUnited Therapeutics
Last Modified on20 October 2022

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